Severity, course trajectory, and within-person variability of individual symptoms in patients with major depressive disorder
| Autor: | A.M. van Hemert, W. A. van Eeden, Brenda W.J.H. Penninx, Erik J. Giltay, Ingrid V. E. Carlier |
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| Přispěvatelé: | APH - Mental Health, Psychiatry, APH - Digital Health |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Psychometrics affective disorders Severity of Illness Index Suicidal Ideation Cohort Studies 03 medical and health sciences 0302 clinical medicine Outcome Assessment Health Care medicine Humans Cognitive Dysfunction In patient Suicidal ideation Depression (differential diagnoses) Netherlands Psychiatric Status Rating Scales Depressive Disorder Major Biological Variation Individual Mood Disorders business.industry Anhedonia Original Articles Middle Aged medicine.disease psychopathology 030227 psychiatry Psychiatry and Mental health Medically Unexplained Symptoms Mood depression Anxiety Major depressive disorder Original Article Female medicine.symptom business 030217 neurology & neurosurgery Clinical psychology Psychopathology |
| Zdroj: | van Eeden, W A, van Hemert, A M, Carlier, I V E, Penninx, B W & Giltay, E J 2019, ' Severity, course trajectory, and within-person variability of individual symptoms in patients with major depressive disorder ', Acta Psychiatrica Scandinavica, vol. 139, no. 2, pp. 194-205 . https://doi.org/10.1111/acps.12987 Acta Psychiatrica Scandinavica, 139(2), 194-205 Acta Psychiatrica Scandinavica |
| ISSN: | 0001-690X |
| DOI: | 10.1111/acps.12987 |
| Popis: | BackgroundDepression shows a large heterogeneity of symptoms between and within persons over time. However, most outcome studies have assessed depression as a single underlying latent construct, using the sum score on psychometric scales as an indicator for severity. This study assesses longitudinal symptom-specific trajectories and within-person variability of major depressive disorder over a 9-year period.MethodsData were derived from the Netherlands Study of Depression and Anxiety (NESDA). This study included 783 participants with a current major depressive disorder at baseline. The Inventory Depressive Symptomatology-Self-Report (IDS-SR) was used to analyze 28 depressive symptoms at up to six time points during the 9-year follow-up.ResultsThe highest baseline severity scores were found for the items regarding energy and mood states. The core symptoms depressed mood and anhedonia had the most favorable course, whereas sleeping problems and (psycho-)somatic symptoms were more persistent over 9-year follow-up. Within-person variability was highest for symptoms related to energy and lowest for suicidal ideation.ConclusionsThe severity, course, and within-person variability differed markedly between depressive symptoms. Our findings strengthen the idea that employing a symptom-focused approach in both clinical care and research is of value. |
| Databáze: | OpenAIRE |
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