Internal dynamics of a supramolecular nanofibre
| Autor: | Brian M. Hoffman, John B. Matson, Julia H. Ortony, Peter E. Doan, Christina J. Newcomb, Samuel I. Stupp, Liam C. Palmer |
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| Rok vydání: | 2014 |
| Předmět: |
Circular dichroism
Nanostructure Kinetics Molecular Conformation Nanofibers Supramolecular chemistry Nanotechnology 02 engineering and technology Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences Protein Structure Secondary Article Diffusion Molecular dynamics Protein structure Microscopy Electron Transmission Molecule General Materials Science Chemistry Circular Dichroism Mechanical Engineering Cryoelectron Microscopy Dynamics (mechanics) Electron Spin Resonance Spectroscopy General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Mechanics of Materials Spin Labels Peptides 0210 nano-technology |
| Zdroj: | Nature materials |
| ISSN: | 1476-4660 1476-1122 |
| DOI: | 10.1038/nmat3979 |
| Popis: | A large variety of functional self-assembled supramolecular nanostructures have been reported over recent decades.1 The experimental approach to these systems initially focused on the design of molecules for specific interactions that lead to discrete geometric structures.1–4 Recently, kinetics and mechanistic pathways of self-assembly have been investigated,6,7 but there remains a major gap in our understanding of internal conformational dynamics and their links to function. This challenge has been addressed through computational chemistry with the introduction of molecular dynamics (MD) simulations, which yield information on molecular fluctuations over time.5–7 Experimentally, it has been difficult to obtain analogous data with sub-nanometer spatial resolution. Thus, there is a need for experimental dynamics measurements, to confirm and guide computational efforts and to gain insight into the internal motion in supramolecular assemblies. Using site-directed spin labeling and electron paramagnetic resonance (EPR) spectroscopy, we measured conformational dynamics through the 6.7 nm cross-section of a self-assembled nanofiber in water and provide unique insight for the design of supramolecular functional materials. |
| Databáze: | OpenAIRE |
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