Artificial Intelligence for the Detection of Diabetic Retinopathy in Primary Care: Protocol for Algorithm Development
| Autor: | Miguel A Zapata, Josep Vidal-Alaball, Oscar Solans Fernandez, Dídac Royo Fibla, Francesc X Marin-Gomez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
020205 medical informatics
Computer science 02 engineering and technology fundus oculi Convolutional neural network 03 medical and health sciences 0302 clinical medicine 0202 electrical engineering electronic engineering information engineering medicine Protocol 030212 general & internal medicine Prospective cohort study Set (psychology) Protocol (science) business.industry Confusion matrix computer assisted diagnosis General Medicine Diabetic retinopathy medicine.disease artificial intelligence Identifier neural network computer diabetic retinopathy Cohort diabetes mellitus Artificial intelligence business Algorithm |
| Zdroj: | JMIR Research Protocols |
| ISSN: | 1929-0748 |
| Popis: | Background: Diabetic retinopathy (DR) is one of the most important causes of blindness worldwide, especially in developed countries. In diabetic patients, periodic examination of the back of the eye using a nonmydriatic camera has been widely demonstrated to be an effective system to control and prevent the onset of DR. Convolutional neural networks have been used to detect DR, achieving very high sensitivities and specificities. Objective: The objective of this is paper was to develop an artificial intelligence (AI) algorithm for the detection of signs of DR in diabetic patients and to scientifically validate the algorithm to be used as a screening tool in primary care. Methods: Under this project, 2 studies will be conducted in a concomitant way: (1) Development of an algorithm with AI to detect signs of DR in patients with diabetes and (2) A prospective study comparing the diagnostic capacity of the AI algorithm with respect to the actual system of family physicians evaluating the images. The standard reference to compare with will be a blinded double reading conducted by retina specialists. For the development of the AI algorithm, different iterations and workouts will be performed on the same set of data. Before starting each new workout, the strategy of dividing the set date into 2 groups will be used randomly. A group with 80% of the images will be used during the training (training dataset), and the remaining 20% images will be used to validate the results (validation dataset) of each cycle (epoch). During the prospective study, true-positive, true-negative, false-positive, and false-negative values will be calculated again. From here, we will obtain the resulting confusion matrix and other indicators to measure the performance of the algorithm. Results: Cession of the images began at the end of 2018. The development of the AI algorithm is calculated to last about 3 to 4 months. Inclusion of patients in the cohort will start in early 2019 and is expected to last 3 to 4 months. Preliminary results are expected to be published by the end of 2019. Conclusions: The study will allow the development of an algorithm based on AI that can demonstrate an equal or superior performance, and that constitutes a complement or an alternative, to the current screening of DR in diabetic patients. International Registered Report Identifier (IRRID): PRR1-10.2196/12539 |
| Databáze: | OpenAIRE |
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