Reduced uptake of [11C]‐ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer’s dementia

Autor: Alfred Buck, Husam Suliman, Roger M. Nitsch, Andreas Buchmann, Christoph Hock, Simon M. Ametamey, Anton F. Gietl, Valerie Treyer, Anass Johayem, Esmeralda Gruber, Rafael Meyer, Paul G. Unschuld
Přispěvatelé: University of Zurich, Treyer, Valerie
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
hippocampus
Pyridines
Hippocampus
610 Medicine & health
mGLUR5
Amygdala
050105 experimental psychology
metabolic glutamate receptor
lcsh:RC321-571
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Alzheimer Disease
Internal medicine
2802 Behavioral Neuroscience
Neuroplasticity
Oximes
Medicine
Dementia
Humans
0501 psychology and cognitive sciences
ABP688
Carbon Radioisotopes
Cerebral perfusion pressure
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Original Research
Aged
Alzheimer's dementia
business.industry
Metabotropic glutamate receptor 5
05 social sciences
amygdala
Brain
10181 Clinic for Nuclear Medicine
11359 Institute for Regenerative Medicine (IREM)
medicine.disease
Endocrinology
medicine.anatomical_structure
Cerebral blood flow
10036 Medical Clinic
Metabotropic glutamate receptor
Positron-Emission Tomography
business
030217 neurology & neurosurgery
Zdroj: Brain and Behavior
Brain and Behavior, Vol 10, Iss 6, Pp n/a-n/a (2020)
Brain and Behavior, 10 (6)
ISSN: 2162-3279
Popis: Introduction Metabotropic glutamate receptors play a critical role in the pathogenesis of Alzheimer's disease due to their involvement in processes of memory formation, neuroplasticity, and synaptotoxity. The objective of the current study was to study mGluR5 availability measured by [11C]‐ABP688 (ABP) in patients with clinically diagnosed Alzheimer's dementia (AD). Methods A bolus‐infusion protocol of [11C]‐ABP688 was applied in 9 subjects with AD and 10 cognitively healthy controls (Controls) to derive distribution volume estimates of mGluR5. Furthermore, we also estimated cerebral perfusion by averaging early frame signal of initial ABP bolus injection. Results Subjects with Alzheimer's dementia (mean age: 77.3/SD 5.7) were older than controls (mean age: 68.5/SD : 9.6) and scored lower on the MMSE (22.1/SD2.7 vs. 29.0/SD0.8). There were no overall differences in ABP signal. However, distribution volume ratio (DVR) for ABP was reduced in the bilateral hippocampus (AD: 1.34/SD : 0.40 vs. Control: 1.84/SD :0.31, p = .007) and the bilateral amygdala (AD:1.86/SD :0.26 vs. Control:2.33/SD :0.37 p = .006) in AD patients compared to controls. Estimate of cerebral blood flow was reduced in the bilateral hippocampus in AD (AD:0.75/SD :0.10 vs. Control:0.86/SD :0.09 p = .02). Conclusion Our findings demonstrate reduced mGluR5 binding in the hippocampus and amygdala in Alzheimer's dementia. Whether this is due to synaptic loss and/or consecutive reduction of potential binding sites or reflects disease inherent mechanisms remains to be elucidated in future studies.
Brain and Behavior, 10 (6)
ISSN:2162-3279
Databáze: OpenAIRE
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