Association of Toll-like receptors 4 (TLR-4) gene expression and polymorphisms in patients with severe asthma
| Autor: | Najah R. Hadi, Rehab Al-Maliki, Rawaa Behlul Al-Fatlawi, Ali Aridhee, Hayder A. Al-Aubaidy, Kifah Alyaqubi, Ali Al-Ameri, Rasha Hatem Dosh, Wasan Hamid Shukur |
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| Rok vydání: | 2021 |
| Předmět: |
Genotype
Gene Expression Immunoglobulin E Polymorphism Single Nucleotide polymorphism Pathogenesis Immune system Polymorphism (computer science) Medicine Humans Genetic Predisposition to Disease Allele Genotyping innate immunity Asthma Uncategorized Polymorphism Genetic biology business.industry TLR-4 asthma General Medicine asthma medicine.disease Toll-like receptors Toll-Like Receptor 4 Immunology biology.protein Tumor necrosis factor alpha Original Article IgE business |
| Zdroj: | Journal of Medicine and Life |
| ISSN: | 1844-3117 |
| Popis: | Innate immunity plays a central role in the pathogenesis of severe asthma, and it is closely linked to elevated IgE and Toll-like receptor 4 (TLR-4) levels. However, there is a scarcity of information about the association of the TLR-4 receptor polymorphism in the pathogenesis of severe asthma. This study highlights the level of gene expression of different alleles in asthmatic patients compared to healthy control individuals. This was a randomized control trial, which included 150 patients with asthma (with high serum levels of IgE) with a matching 150 healthy control individuals. Participants had a series of blood tests to measure various immune parameters: interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor (TNF), intercellular adhesion molecule-1 (ICAM1) and detect allele type and gene expression of the TLR-4 gene. Patients with asthma had significantly higher levels of IL-8 when compared to the healthy control participants. In addition, in the rs91 genotyping, there were significant differences in the levels of IL-8 and TNF between CC and TT genotyping. While in rs90 TLR-4, TNF levels were significantly higher in AA vs. AG and GG genotypes among the asthmatic patients when compared to the control group. The results showed that in TLR-4, rs4986791 were significantly associated with asthma risk. Polymorphisms in TLRs play essential roles in asthma. |
| Databáze: | OpenAIRE |
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