Unsatisfactory Short-Term Neurodevelopmental Outcomes of Preterm Infants Who Received Polymyxin B-Immobilized Fiber Column-Direct Hemoperfusion for Septic Shock
| Autor: | Kaoru Obinata, Taiki Shima, Akiko Watanabe, Naoto Nishizaki, Toshiaki Shimizu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male endocrine system medicine.medical_treatment Nervous System Polymyxin b immobilized fiber General Biochemistry Genetics and Molecular Biology Sepsis Interquartile range medicine Humans Polymyxin B Periventricular leukomalacia Septic shock business.industry Infant Newborn General Medicine medicine.disease Hemoperfusion Shock Septic Intraventricular hemorrhage Shock (circulatory) Anesthesia Female medicine.symptom business Infant Premature |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 253:275-281 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.253.275 |
| Popis: | Sepsis and septic shock are associated with high mortality and neurodevelopmental impairment in preterm infants. Recently, endotoxin and mediator removal using a polymyxin B-immobilized fiber column for direct hemoperfusion (PMX-DHP) has been used for the management of septic shock even in neonates. Although early withdrawal from shock with PMX-DHP contributes to survival, its effect on neurodevelopment after discharge is unclear. This study aimed to examine short-term neurodevelopmental impairment in preterm infants with septic shock who were treated with PMX-DHP. We retrospectively assessed five infants who received treatment with PMX-DHP (median 25.5 [interquartile range: 24.8-28.3] weeks and 817 [interquartile range: 667-954] g). Neurodevelopmental outcomes were assessed with the Kyoto Scale of Psychological Development 2001 at a median 34.5 (interquartile range: 29.5-44.5) months of corrected age after discharge. The short-term neurodevelopmental prognosis of preterm infants treated with PMX-DHP for septic shock was delayed (overall developmental quotient < 70) with an average quotient of 57.3. Furthermore, four (80%) of five patients presented with intraventricular hemorrhage and another four (80%) with periventricular leukomalacia. In conclusion, preterm infants with septic shock treated with PMX-DHP had unsatisfactory short-term neurodevelopmental outcomes. Hence, the effect of PMX-DHP in improving neurodevelopmental prognosis even in preterm infants with septic shock should be further evaluated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|