Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells
| Autor: | Shih Lu Wu, Li-Jen Lin, Tin-Yun Ho, Shung Te Kao, De Cheng Chao, Chih-Shiang Chang, Chien-Yun Hsiang, Ji An Liang, Hui-Chi Huang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Carcinoma
Hepatocellular Berberine Pharmacology Evodia chemistry.chemical_compound Evodiamine Drug Discovery Humans Medicine biology Traditional medicine Plant Extracts business.industry Liver Neoplasms NF-kappa B NF-κB Hep G2 Cells General Medicine Coptis chinensis biology.organism_classification NFKB1 Coptis Antineoplastic Agents Phytogenic digestive system diseases Transcription Factor AP-1 Cell Transformation Neoplastic chemistry Tetradecanoylphorbol Acetate Quinazolines Tumor promotion business Drugs Chinese Herbal |
| Zdroj: | Fitoterapia. 82:696-703 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2011.02.009 |
| Popis: | Zuo-Jin-Wan (ZJW) has been used to treat hepatocellular carcinoma in Asia. This study was to determine whether ZJW and its components blocked activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities as well as tumor promotion in hepatoblastoma HepG2 cells. ZJW and its components, Coptis chinensis and Evodia rutaecarpa, inhibited AP-1 and NF-κB activities, and suppressed anchorage-independent growth of HepG2 cells. The major alkaloidal ingredients, berberine and evodiamine, inhibited AP-1 activities and/or NF-κB activation, and further suppressed hepatocellular transformation. In conclusion, ZJW and its constituents, berberine and evodiamine, suppressed tumor promotion primarily through AP-1 and/or NF-κB pathways in HepG2 cells. |
| Databáze: | OpenAIRE |
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