Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats

Autor: Vijay Kumar Daroji, Venkatachalam Hillemane, B. S. Jayashree, Mazhuvancherry Kesavan Unnikrishnan, Yogendra Nayak
Rok vydání: 2014
Předmět:
Blood Glucose
Glycation End Products
Advanced
Male
endocrine system diseases
medicine.medical_treatment
lcsh:Medicine
Pharmacology
lcsh:Technology
Glibenclamide
Coumarins
Insulin
Medicine
lcsh:Science
General Environmental Science
Glucose tolerance test
medicine.diagnostic_test
Fasting
General Medicine
Lipids
Liver
Creatinine
Benzopyrone
Glycogen
Research Article
medicine.drug
Niacinamide
medicine.medical_specialty
Article Subject
Streptozocin
General Biochemistry
Genetics and Molecular Biology
Diabetes Mellitus
Experimental
Insulin resistance
Internal medicine
Diabetes mellitus
Animals
Hypoglycemic Agents
Rats
Wistar
Pancreas
lcsh:T
business.industry
lcsh:R
Insulin tolerance test
nutritional and metabolic diseases
Glucose Tolerance Test
medicine.disease
Streptozotocin
Oxidative Stress
Endocrinology
Diabetes Mellitus
Type 2
Hyperglycemia
lcsh:Q
Insulin Resistance
business
Biomarkers
Zdroj: The Scientific World Journal, Vol 2014 (2014)
The Scientific World Journal
ISSN: 1537-744X
2356-6140
DOI: 10.1155/2014/854267
Popis: Benzopyrones are proven antidiabetic drug candidate in diabetic drug discovery. In this view novel synthetic benzopyrone analogues were selected for testing in experimental diabetes. Type 2 diabetes (T2D) was induced in Wistar rats by streptozotocin (60 mg/kg, i.p.) followed by nicotinamide (120 mg/kg i.p.). Rats having fasting blood glucose (FBG) >200 mg/dL, 7 days after T2D-induction, are selected for the study. Test compounds and standard treatment were continued for 15 days. FBG, oral glucose tolerance test (OGTT), and insulin tolerance test (ITT) were determined on 21st day after induction of T2D. Plasma lipids and serum insulin were estimated. Homeostatic model assessment (HOMA-IR) was then calculated from serum insulin. Rats were sacrificed and pancreas was isolated for histopathological observations. Oxidative stress markers were estimated in liver homogenate. Quercetin, a natural product with benzopyrone ring, showed significant hypoglycemic activity comparable to glibenclamide. Treatment with test compounds lowered the FBG and insulin resistance was significant alleviated as determined by OGTT, HOMA-IR, and ITT. There was significant normalisation of liver antioxidant enzymes compared to diabetic rats indicating that all the synthesised benzopyrone analogues are beneficial in reducing oxidative stress and are on par with the standard quercetin and glibenclamide in experimental T2D.
Databáze: OpenAIRE
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