Distribution of cardiac output during development of two metastasizing murine tumors
| Autor: | E. Raczka, A. Quintana, Andreina Poggi, Maria Benedetta Donati |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Cardiac output Pathology medicine.medical_specialty Lung Neoplasms Vasodilation Prostacyclin Biology Radioactive microspheres Mice medicine Animals Distribution (pharmacology) Cardiac Output Neoplasm Metastasis Mice Inbred BALB C Lung Cancer Neoplasms Experimental Organ Size medicine.disease Mice Inbred C57BL Transplantation medicine.anatomical_structure Liver Oncology Sarcoma Experimental Spleen medicine.drug |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 19:1021-1029 |
| ISSN: | 0277-5379 |
| DOI: | 10.1016/0277-5379(83)90072-x |
| Popis: | The study of cardiac output (CO) distribution to tumors and metastases is of interest for a better understanding of tumor biology and for pharmacological approaches. A radioactive microsphere method was developed to assess CO distribution in C57BL/6J mice bearing syngeneic 3LL or BALB/c mice with JWS. At the initial stages of cancer growth, the CO relative fractions per g of tissue (%CO/ g ) to 3LL and JWS were similar to those in surrounding tissues. In both tumors a positive, significant correlation was found between tumor weight and tumor CO fraction, but %CO/ g was lower in 3LL 2 and 3 weeks after transplantation, whereas it did not change in JWS. Indeed, much larger necrotic areas developed in 3LL than in JWS. The %CO/ g to the lungs increased in both models when metastases were not yet visible; subsequently, the appearance of lung nodules was accompanied by a decrease of %CO/ g in JWS and a further increase in 3LL. This corresponded to the much higher ratio of metastatic to intact lung tissue in JWS than in 3LL. In fact, isolated lung metastases had a significantly lower blood supply than the surrounding tissue. This might be due to a different vascularization pattern and/or smaller amounts of vasodilator substances being produced by metastatic nodules; the latter is suggested by lower generation of prostacyclin activity in isolated lung metastases than in intact pulmonary tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|