Plasmatic and membrane lipid alterations in erythrocytes from diabetic rats fed either n-6 or n-3 fatty acids
| Autor: | Nelva T. de Gomez Dumm, Ariel Igal |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Glycosylation Fluorescent polarization Lipid composition Clinical Biochemistry Phospholipid Biology Biochemistry Fluorescence Diabetes Mellitus Experimental chemistry.chemical_compound Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 Genetics medicine Animals N-3 fatty acids Rats Wistar Molecular Biology Triglycerides Triglyceride Cholesterol Erythrocyte Membrane Blood Proteins Cell Biology Lipid Metabolism Animal Feed Lipids Red cell membrane Rats Membrane Endocrinology chemistry Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Diphenylhexatriene |
| Zdroj: | IUBMB Life. 40:459-467 |
| ISSN: | 1521-6543 |
| DOI: | 10.1080/15216549600201023 |
| Popis: | We examined the effect of dietary n-6 and n-3 fatty acids on the lipid composition and physical properties of erythrocyte membranes together with cholesterol and triglyceride plasmatic levels in normal and experimental diabetic rats. Plasmatic total cholesterol and triglyceride did not change in normal rats under the dietary regime, but both parameters decreased significantly in the diabetic animals after the consumption of either n-6 or n-3 fatty acids. Lipid analyses of erythrocyte membranes revealed a significant decrease in the total cholesterol together with an increase in the phospholipid amount in the diabetics compared to the normal rats. As a consequence, cholesterol/phospholipid ratio decreased in these groups of animals and markedly in those fed n-3 fatty acids. These changes would be responsible for the lower fluorescent polarization of DPH observed in the latter group. We conclude that equivalent and adequate amounts of dietary either n-6 or n-3 fatty acids produce plasmatic and red cell membrane lipid changes in diabetic rats that may improve the evolution of the disease. |
| Databáze: | OpenAIRE |
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