Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy
| Autor: | Matthias Rothermundt, Daniel Martins-de-Souza, Hassan Rahmoune, Paul C. Guest, Viktoria Stelzhammer, Sabine Bahn, Wolfgang Kluge, Carina Sondermann, Nikolaus Michael |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Proteomics medicine.drug_class medicine.medical_treatment Clinical Biochemistry Succinylcholine Pharmacology 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Humans Medicine Anesthesia Clinical significance Electroconvulsive Therapy Depressive Disorder Major business.industry Insulin Interleukin Muscle relaxant Middle Aged medicine.disease Prolactin 3. Good health 030227 psychiatry Neuromuscular Depolarizing Agents Methohexital Major depressive disorder Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | PROTEOMICS-Clinical Applications; Vol 5 |
| ISSN: | 1862-8346 |
| DOI: | 10.1002/prca.201100040 |
| Popis: | Purpose: Electroconvulsive therapy (ECT) is a psychiatric treatment in which seizures are electrically induced in patients. Prior to treatment, patients are usually given short-acting anaesthetics and muscle relaxants to avoid harm, e.g. musculoskeletal injury, during the convulsions. However, most molecular studies investigating the mechanism of action of ECT have not explored the potential effects of the pre-treatment with anaesthetic and/ or muscle relaxant. Experimental design: We have carried out a targeted proteome analysis using multiplex immunoassay platform of serum samples before and 10 min after initiating the administration of the anaesthetic methohexital® and the muscle relaxant succinylcholine® to eight major depressive disorder patients undergoing ECT. Results: Twenty-six out of 142 analysed molecules showed significant differences in abundance after the methohexital/succinylcholine treatment. Importantly, eight of these molecules (fatty acid-binding protein, insulin, interleukin (IL)1β, IL-10, IL-4, prolactin, S100 calcium-binding protein B and tumor necrosis factor α) have been associated previously with effects of ECT. Conclusions and clinical relevance: These findings indicate that caution should be used when interpreting results in existing and future proteome-based biomarkers studies on the effects of ECT in neuropsychiatric disease or the use of anaesthetic/muscle relaxant in major surgical operations related to different therapeutic areas. |
| Databáze: | OpenAIRE |
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