Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: Evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss
| Autor: | Torben Houman Andersen, Per Bech, Niels-Erik Larsen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Olanzapine Perphenazine medicine.medical_specialty Exacerbation Denmark medicine.medical_treatment Pilot Projects Buspirone Benzodiazepines Basal Ganglia Diseases Weight loss Weight Loss medicine Humans Psychiatry Antipsychotic Risperidone business.industry Middle Aged Serotonin Receptor Agonists Psychiatry and Mental health Anesthesia Schizophrenia Drug Therapy Combination Female Schizophrenic Psychology medicine.symptom business Weight gain Antipsychotic Agents medicine.drug |
| Zdroj: | Nordic Journal of Psychiatry. 59:205-208 |
| ISSN: | 1502-4725 0803-9488 |
| DOI: | 10.1080/08039480510027689 |
| Popis: | In this pilot study, we have investigated the effects of switching from olanzapine or risperidone treatment to low-dose perphenazine combined with buspirone in six schizophrenic patients who had experienced weight gain. We found no relapse as to psychotic symptoms measured by the CGI-S scale and no exacerbation of extrapyramidal side-effects as measured by the Simpson-Angus Scale. In addition, we observed a medium weight reduction of 10.5 kg (range 1-20 kg). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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