Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
| Autor: | Sebastián Triviño, J. Vedelago, María del Mar Montesinos, Facundo Mattea, Walter Keil, Marcelo Ariel Romero, Mauro Valente |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Boron Compounds
Materials science Magnetic Resonance Spectroscopy Chemical Phenomena Polymers Science Monte Carlo method Physics::Medical Physics chemistry.chemical_element Nanotechnology 02 engineering and technology Isotopes of boron 010402 general chemistry Smart material 01 natural sciences Article Radiation Ionizing Polyamines Neutron Boron Polyhydroxyethyl Methacrylate Drug Carriers Multidisciplinary Molecular Structure 021001 nanoscience & nanotechnology Neutron temperature Sensors and biosensors 0104 chemical sciences Neutron capture Cross-Linking Reagents chemistry Medicine Functional polymers 0210 nano-technology Actuators |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and particularly as functional polymers like boron carriers for cancer therapy. There are two main applications of boron isotopes in radiation cancer therapy, Boron Neutron Capture Therapy and Proton Boron Fusion Therapy. In this study, a novel and original material consisting of a three-dimensional polymer network crosslinked with $$^{10}$$ 10 B enriched boric acid molecules is proposed and synthesized. The effects of the exposition to thermal neutrons were studied analyzing changes in the mechanical properties of the proposed material. Dedicated Monte Carlo simulations, based on MCNP and FLUKA main codes, were performed to characterize interactions of the proposed material with neutrons, photons, and charged particles typically present in mixed fields in nuclear reactor irradiations. Experimental results and Monte Carlo simulations were in agreement, thus justifying further studies of this promising material. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |