1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect
| Autor: | Anita Gulbe, Edvards Liepinsh, Ruslan Muhamadejev, Pavel Arsenyan, Ilona Domracheva, Gunars Duburs, I. Shestakova, Marina Petrova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Health
Toxicology and Mutagenesis Short Communication Cytotoxicity 5-Fluorouracil Toxicology Carmofur 1-hexylcarbamoyl-5-fluorouracil chemistry.chemical_compound lcsh:RA1190-1270 5-Fluorouracil (PubChem CID: 3385) DMPC 1 2-dimyristoyl-sn-glycero-3-phosphocholine Neutral ph NMR nuclear magnetic resonance 1-Hexylcarbamoyl-5-fluorouracil (PubChem CID: 2577) lcsh:Toxicology. Poisons Phosphocholine ComputingMethodologies_COMPUTERGRAPHICS Chromatography 5-Fu 5-fluorouracil technology industry and agriculture 1 2-Dimyristoyl-sn-glycero-3-phosphocholine (PubChem CID: 5459377) 1H NMR In vitro Carmofur chemistry Drug delivery Proton NMR Biophysics DMPC lipids (amino acids peptides and proteins) Antiproliferative effect |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 2, Iss C, Pp 377-383 (2015) |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • DMPC addition stabilizes Carmofur at neutral pH. • We report considerable increase of Carmofur cytotoxicity. • It opens a way for the drug delivery of Carmofur in neutral and basic media. Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by 1H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media. |
| Databáze: | OpenAIRE |
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