Association of CD31 and p53 With Survival of Ovarian Cancer Patients

Autor: Allan Jensen, Jan Blaakær, Lene Rask, Estrid Høgdall, Lise Christensen, Susanne K. Kjaer, Ib Jarle Christensen, Claus Høgdall
Rok vydání: 2018
Předmět:
Platelet Endothelial Cell Adhesion Molecule-1/metabolism
Carcinoma
Ovarian Epithelial/metabolism
Oncology
CD31
Cancer Research
medicine.medical_specialty
Denmark
Cell
Kaplan-Meier Estimate
Carcinoma
Ovarian Epithelial
03 medical and health sciences
0302 clinical medicine
Ovarian cancer
Risk Factors
Internal medicine
medicine
Biomarkers
Tumor
Humans
Stage (cooking)
Tumor Suppressor Protein p53/metabolism
Neoplasm Staging
Ovarian Neoplasms
P53
business.industry
Gene Expression Profiling
Hazard ratio
Cancer
Cell Differentiation
General Medicine
Ovarian Neoplasms/metabolism
medicine.disease
Prognosis
Immunohistochemistry
Gene expression profiling
Gene Expression Regulation
Neoplastic
Platelet Endothelial Cell Adhesion Molecule-1
medicine.anatomical_structure
Biomarkers
Tumor/metabolism
030220 oncology & carcinogenesis
Disease Progression
Female
Tumor Suppressor Protein p53
business
Zdroj: Rask, L, Høgdall, C K, Kjaer, S K, Christensen, L, Jensen, A, Blaakaer, J, Christensen, I J & Høgdall, E V S 2019, ' Association of CD31 and p53 with survival of ovarian cancer patients ', Anticancer Research, vol. 39, no. 2, pp. 567-576 . https://doi.org/10.21873/anticanres.13149
ISSN: 1791-7530
DOI: 10.21873/anticanres.13149
Popis: Background/Aim: New markers for ovarian cancer are needed. This study aimed to examine the expression of tumour cell p53 and endothelial cell CD31 proteins and correlate them to clinicopathological factors. Patients and Methods: Expression of proteins was immunohistochemically assessed using tissue sections from 585-599 ovarian cancer patients from the Danish MALOVA study. Results: High CD31 expression was found in poorly differentiated tumours (p=0.0006), and high p53 expression was found in poorly differentiated cancers (p
Databáze: OpenAIRE
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