Hepatoregenerative role of bone morphogenetic protein-9
| Autor: | Lucian Vukelic, Drazen Cuculic, Olga Cvijanović, Sanja Zoričić Cvek, Ivan Šoša, Tanja Ćelić, Zeljka Crncevic-Orlic, Alan Bosnar, Luka Dudaric, Dragica Bobinac |
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| Rok vydání: | 2011 |
| Předmět: |
insulin
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences medicine.medical_specialty animal structures medicine.medical_treatment GDF2 Carbohydrate metabolism Biology Models Biological Mice Internal medicine Growth Differentiation Factor 2 medicine Animals Humans Insulin BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences General Medicine Transforming growth factor beta Hypothesis Liver regeneration Liver Regeneration bone morphogenetic protein-9 Endocrinology GDF10 embryonic structures biology.protein GDF15 Signal transduction BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti liver organization |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Medical science monitor Volume 17 Issue 12 |
| ISSN: | 1234-1010 |
| DOI: | 10.12659/msm.882108 |
| Popis: | Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) super-family of cytokines, which regulate cell growth and differentiation during embryogenesis. Apart of that, the hypoglycemic potential of BMP-9 is of great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice and regulates directional glucose metabolism in hepatocytes ; therefore it is proposed to be a candidate hepatic insulin-sensitizing substance (HISS). In liver fibrosis, due to the portocaval shunt, insulin bypasses the organ and the liver undergoes atrophy. Parenteral administration of insulin reverses atrophy by stimulating mitogenic activity of the hepatocytes. Because BMP-9 has a signaling pathway similar to other BMPs and insulin, it is to be expected that BMP-9 has a certain regenerative role in the liver. Also supporting the above-mentioned is evidence of BMP- 9 expression in Dissè's spaces and BMP-7’s mitogenic activity in mucosal cells. However, further studies are needed to confirm the possible regenerative role of BMP-9. |
| Databáze: | OpenAIRE |
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