The effect of indomethacin on systemic and renal hemodynamics in neonatal piglets during experimental endotoxemia
| Autor: | Adisorn Lumpaopong, Sema Rao Gorla, Ulf H. Beier, Linda Fornell, Nicholas F. Furtado, Eunice John, Jayant Radhakrishnan |
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| Rok vydání: | 2008 |
| Předmět: |
Mean arterial pressure
medicine.medical_specialty Swine Indomethacin Urology Hemodynamics Renal function Blood Pressure Nephrotoxicity Renal Circulation Heart Rate Medicine Animals Escherichia coli Infections Renal circulation business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Endotoxemia Disease Models Animal medicine.anatomical_structure Blood pressure Treatment Outcome Animals Newborn Anesthesia Renal blood flow Pediatrics Perinatology and Child Health Vascular resistance Surgery business Blood Flow Velocity Glomerular Filtration Rate |
| Zdroj: | Pediatric surgery international. 24(8) |
| ISSN: | 0179-0358 |
| Popis: | Systemic and renal hemodynamics are affected by prostaglandin production during endotoxemia. To study indomethacin effects on endotoxinemia in a neonatal piglet model, sixteen 7–10 day old piglets were anesthetized, ventilated, and catheterized. Mean arterial pressure (MAP), heart rate (HR), and urine output were continuously monitored. Endotoxin (0.06 mcg/kg) was injected after baseline measurements. We studied two groups with either endotoxinemia alone (n = 7) or an additional indomethacin infusion (0.2 mg/kg per h, n = 9). HR, MAP, renal blood flow (RBF), systemic and renal vascular resistance (SVR, RVR), cardiac index (CI), and glomerular filtration rate (GFR), were obtained at baseline, at 1, 2 and 3 h. We observed a drop in CI and an increase in SVR and HR within 3 h of endotoxinemia, while MAP remained unchanged. These effects were prevented by indomethacin. RVR was not altered significantly. Endotoxinemia triggered a drop of RBF in both control (P < 0.01) and intervention group (P < 0.05). In the intervention group, drop of GFR, urine volume, and paraaminohippuric acid clearance were apparent signs of nephrotoxicity (P < 0.01 |
| Databáze: | OpenAIRE |
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