The SOCS-1 gene methylation in chronic myeloid leukemia patients
| Autor: | Ugur Ozbek, Teoman Soysal, Burhan Ferhanoglu, Ozden Hatirnaz, Tayfun Ozcelik, Cemaliye B Akyerli, Cem Ar, Umit Ure |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Adult Leukemia Myeloid Chronic SOCS 1 gene Exon Suppressor of Cytokine Signaling Proteins STAT protein Major clinical study Biology Gene Article BCR ABL protein Cancer growth Suppressor of Cytokine Signaling 1 Protein Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases medicine Humans Priority journal DNA methylation Leukemogenesis Chronic myeloid leukemia Promoter region Myeloid leukemia Promoter Hematology Methylation Exons DNA Methylation Middle Aged medicine.disease Leukemia suppressor of cytokine signaling 1 SOCS1 Gene Cancer research Protein protein interaction Cancer patient Female Controlled study Janus kinase Human |
| Zdroj: | American Journal of Hematology |
| Popis: | SOCS-1, an important protein in the JAK/STAT pathway, has a role in the down stream of BCR-ABL protein kinase. We investigated 56 CML patients and 16 controls for the methylation status of SOCS-1 gene promoter and Exon 2 regions. Exon 2 was found to be methylated in 58.9% of the patients and 93.8% of the controls [P = 0.020, OR = 0.121(0.015-0.957)%95CI]. The promoter region was found unmethylated in all patient samples and controls. Although previous studies revealed a relation between SOCS1 gene Exon-2 hypermethylation and CML development or progression, the results of this study showed no such correlation. On the contrary, our results might be indicating hypomethylation in CML patients, this hypothesis need to be studied in larger study population. |
| Databáze: | OpenAIRE |
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