Nitric Oxide Levels in Preterm and Term Infants and in Premature Infants with Bacteremia
| Autor: | Lea Sirota, Daphna Marom, Shai Ashkenazi, Yael Yuhas, Gilat Livni |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Neonatal intensive care unit Staphylococcus Enterobacter Bacteremia Gestational Age Infant Premature Diseases Nitric Oxide Gastroenterology Nitric oxide chemistry.chemical_compound Internal medicine Escherichia coli medicine Humans Blood culture Neonatology Prospective cohort study medicine.diagnostic_test business.industry Obstetrics Infant Newborn Gestational age medicine.disease Klebsiella pneumoniae chemistry Pediatrics Perinatology and Child Health Gestation Female business Infant Premature Developmental Biology |
| Zdroj: | Neonatology. 86:160-164 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | Objective: To determine the serum nitric oxide levels in healthy neonates and in infants with bacteremia. Methods: We performed a prospective study in a tertiary neonatal intensive care unit. The serum nitric oxide levels were measured in all infants at birth (basal) and in the infected neonates also on the first 2 days of bacteremia. Results: Thirty-three neonates (10 term, 23 preterm) were included. Eleven preterm infants (mean gestational age 27 weeks) had bacteremia. The main blood culture isolates included coagulase-negative staphylococci (n = 4), Klebsiella pneumoniae (n = 3), and Escherichia coli (n = 3). The serum nitric oxide levels increased during infection in 10 infants (p < 0.008). The mean nitric oxide level before infection was 44 µM and during infection 96 µM (p = 0.008). In the healthy babies, the mean nitric oxide level was 26 µM in those with a gestational age M in those born between 28 and 36 weeks of gestation, and 63 µM in term infants. Conclusions: Bacteremic preterm infants produce significantly higher amounts of nitric oxide. The basal nitric oxide levels at birth may be correlated with gestational age. |
| Databáze: | OpenAIRE |
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