Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women
| Autor: | Sairish Ashraf, Mudasar Nabi, Shayaq Ul Abeer Rasool, Shajrul Amin, Mohd Ashraf Ganie, Shariq Rashid Masoodi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Genotype Science Biochemistry Polymorphism Single Nucleotide Article Young Adult 03 medical and health sciences Endocrinology Aromatase Sex Factors 0302 clinical medicine Gene Frequency Risk Factors Polymorphism (computer science) Internal medicine Genetics Odds Ratio medicine Humans Genetic Predisposition to Disease Allele frequency Alleles Genetic Association Studies Testosterone 030219 obstetrics & reproductive medicine Multidisciplinary Models Genetic business.industry Hyperandrogenism Case-control study medicine.disease Polycystic ovary Genotype frequency 030104 developmental biology Case-Control Studies Medicine Female business Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in pre-menopausal women having complex pathophysiology. Several candidate genes have been shown to have association with PCOS. CYP19 gene encodes a key steroidogenic enzyme involved in conversion of androgens into estrogens. Previous studies have reported contradictory results with regard to association of SNP rs2414096 in CYP19 gene with PCOS and hyperandrogenism in different ethnic populations. Present study was aimed to investigate the impact of SNP rs2414096 polymorphism of CYP19 gene on susceptibility of PCOS and hyperandrogenism in Kashmiri women. Further we also studied the genotypic-phenotypic association for various clinical and biochemical parameters of this polymorphism. Case control study. 394 PCOS cases diagnosed on the basis of Rotterdam criteria and age matched 306 healthy women. We found a significant differences in genotypic frequency (χ2 = 18.91, p 2 = 17.66, p CYP19 gene is associated with the risk of PCOS as well as with clinical and biochemical markers of hyperandrogenism, hence suggesting its role in clinical manifestations of PCOS in Kashmiri women. |
| Databáze: | OpenAIRE |
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