Contrast enhancement of magnetic resonance images by chromium EDTA: an experimental study
| Autor: | Val M. Runge, Charles M. Lukehart, Francis W. Smith, C L Partain, A E James, Jeffrey A. Clanton, M. Jones, M A Foster, John R. Mallard, James M. S. Hutchison |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Chromium
Magnetic Resonance Spectroscopy chemistry.chemical_element Hydronephrosis Kidney Spin–spin relaxation Nuclear magnetic resonance Ischemia In vivo medicine Animals Radiology Nuclear Medicine and imaging Chelation Sarcoma Yoshida Edetic Acid medicine.diagnostic_test Renal ischemia business.industry Spectrum Analysis Spin–lattice relaxation Brain Rats Inbred Strains Magnetic resonance imaging medicine.disease Rats chemistry Rabbits business Neoplasm Transplantation |
| Zdroj: | Radiology. 152:123-126 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.152.1.6427845 |
| Popis: | Chromium EDTA was evaluated as an intravenous contrast agent for magnetic resonance (MR) imaging in vitro and in vivo in rabbits and rats. The effect of Cr EDTA on T1 and T2 values in vitro was first quantitated by spectroscopy at 2.5 MHz, followed by animal trials in which the effects of intravenous injection of Cr EDTA on calculated T1 MR images (obtained by the spin- warp technique at 1.7 MHz) were determined. Following administration of chromium EDTA, differences in T1 values between normal and abnormal kidneys were noted, renal hydronephrosis and renal ischemia were readily identified by the pattern of change in T1, and changes were observed in the normal rabbit brain and in tumors implanted in rats. It is concluded that the use of stable paramagnetic metal ion chelates, such as Cr EDTA, as intravenous contrast agents in MR imaging is feasible and that such agents would make possible the observation of tissue vascularity, breakdown of the blood-brain barrier, and renal function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|