Diet and Nutraceutical Supplementation in Dyslipidemic Patients: First Results of an Italian Single Center Real-World Retrospective Analysis

Autor: Anna Laura Cremonini, Sabrina Piras, Andrea Pasta, Elena Formisano, Livia Pisciotta, Elio Maganza, Erika Parodi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Mediterranean diet
030204 cardiovascular system & hematology
Single Center
Diet
Mediterranean
Gastroenterology
0302 clinical medicine
Risk Factors
Retrospective analysis
030212 general & internal medicine
dyslipidemias
Nutrition and Dietetics
medicine.diagnostic_test
hypercholesterolemia
Anticholesteremic Agents
Middle Aged
Lipids
Cholesterol
Italy
Acute pancreatitis
Female
lipids (amino acids
peptides
and proteins)
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
hypertriglyceridemia
EAS/ESC guidelines LDL-C targets
lcsh:TX341-641
Article
03 medical and health sciences
Nutraceutical
Internal medicine
nutraceutical supplements
medicine
Humans
Triglycerides
Aged
Retrospective Studies
lipid lowering diet
business.industry
Hypertriglyceridemia
Cholesterol
LDL
medicine.disease
Atherosclerosis
Diet
Pancreatitis
Dietary Supplements
business
Lipid profile
Body mass index
Food Science
Zdroj: Nutrients, Vol 12, Iss 2056, p 2056 (2020)
Nutrients
Volume 12
Issue 7
ISSN: 2072-6643
Popis: Background: Dyslipidemias are a heterogeneous group of metabolic disorders mainly characterized by an increased risk of atherosclerotic cardiovascular disease (ASCVD) or other conditions, such as acute pancreatitis in hypertriglyceridemia. The aim of this study was to evaluate the effect of diet treatment and nutraceutical (NUTs) supplementation on the plasma lipid profile in outpatient dyslipidemic subjects, considering the influence of several factors (i.e., gender, age, body mass index, alcohol consumption, and smoking habits). Methods: 487 dyslipidemic patients spanning from 2015 to 2019 were treated with a Mediterranean diet or NUTs in a real-word setting and were retrospectively analyzed. General characteristics and lipid profile at baseline and after the follow-up period were evaluated. Results: Diet alone reduced total cholesterol (&minus
19 mg/dL, &minus
7.7%), LDL cholesterol (&minus
18 mg/dL, &minus
10.1%), and triglycerides (&minus
20 mg/dL, &minus
16.7%). Triglycerides (TG) decreased more in men, while women were associated with higher reduction of LDL cholesterol (LDL-C). Different types of NUTs further ameliorate lipid profiles when associated with diet. Nevertheless, most patients at low ASCVD risk (222 out of 262, 81.6%) did not achieve the 2019 ESC/EAS guidelines recommended LDL-C goals (i.e., LDL-C <
116 mg/dL). Conclusion: Lipid-lowering diet improves lipid profile, and NUTs can boost its efficacy, but taken together they are mainly unsatisfactory with respect to the targets imposed by 2019 EAS/ESC guidelines.
Databáze: OpenAIRE
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