Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy

Autor: Carel B. Hoyng, Tom Missotten, Gregorius P M Luyten, Suzanne Yzer, Elon H. C. van Dijk, Camiel J. F. Boon, Danial Mohabati, Thomas J. van Rijssen
Přispěvatelé: Ophthalmology, ANS - Cellular & Molecular Mechanisms
Rok vydání: 2018
Předmět:
0301 basic medicine
long-term outcome
medicine.medical_specialty
Visual acuity
genetic structures
chronic central serous chorioretinopathy
severity
Chronic central serous chorioretinopathy
Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
03 medical and health sciences
chemistry.chemical_compound
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Ophthalmology
medicine
posterior cystoid retinal degeneration
Retinal pigment epithelium
medicine.diagnostic_test
treatment
business.industry
Medical record
Retinal
Clinical Ophthalmology
Diabetic retinopathy
Fluorescein angiography
medicine.disease
Phenotype
eye diseases
030104 developmental biology
medicine.anatomical_structure
chemistry
photodynamic therapy
030221 ophthalmology & optometry
sense organs
medicine.symptom
business
Zdroj: Clinical Ophthalmology, 12, 1061-1070
Clinical ophthalmology (Auckland, N.Z.), 12, 1061-1070. Dove Medical Press Ltd.
Clinical Ophthalmology, 12, pp. 1061-1070
ISSN: 1177-5467
Popis: Danial Mohabati,1,2 Thomas J van Rijssen,1 Elon HC van Dijk,1 Gregorius PM Luyten,1 Tom O Missotten,3 Carel B Hoyng,4 Suzanne Yzer,3 Camiel JF Boon1,5 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands; 4Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 5Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Purpose: The aim of this study was to investigate disease onset and disease progression in patients with severe chronic central serous chorioretinopathy (cCSC). Patients and methods: The medical records of 143 cCSC patients (199 eyes) were reviewed. All cases had visual complaints for >6months and showed signs of a severe disease phenotype on optical coherence tomography (OCT) and fluorescein angiography (FA). Clinical presentation at onset was evaluated, together with disease progression on multimodal imaging and final treatment outcome. Results: Twenty-eight cases (14%) had a documented history of an acute episode of CSC, whereas 145 cases (73%) showed pre-existing features of chronicity already at first presentation. The first clinical presentation could not be evaluated in 13% of cases. Best-corrected visual acuity (BCVA) was 70 ± 18 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters at onset and 70 ± 22 ETDRS letters at final visit (p = 0.770). Among all studied cases, 173 eyes (87%) were treated, which resulted in complete resolution of subretinal fluid (SRF) in 76% of eyes at final visit. In eyes with fluorescein angiographic follow-up, the area of diffuse atrophic retinal pigment epithelium (RPE) abnormalities (diffuse atrophic RPE alterations [DARA]) had increased significantly in 43 eyes (68%) at final visit. Conclusion: CSC encompasses a clinical spectrum that includes a range of severe phenotypes, in which retinal abnormalities tend to be progressive. Nevertheless, the long-term visual acuity may remain fairly stable with treatment. Few patients with severe chronic CSC have a history of acute CSC, which could indicate that there may be pathogenetic differences between these 2 CSC variants. Keywords: chronic central serous chorioretinopathy, long-term outcome, severity, treatment, photodynamic therapy, posterior cystoid retinal degeneration
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje