Relationship between the gingival sulcus depth and interleukin-1 isoform concentrations within the adjacent gingival tissue
Autor: | Jennifer L. Bain, Francis G. Serio, Roger B. Johnson, S. R. Lester |
---|---|
Rok vydání: | 2009 |
Předmět: |
Male
Gene isoform Pathology medicine.medical_specialty medicine.drug_class Interleukin-1beta Bleeding on probing Gingiva Dentistry Enzyme-Linked Immunosorbent Assay Gingival Pocket Interleukin-1alpha medicine Humans Protein Isoforms Gingival sulcus Interleukin-6 Chemistry business.industry Antagonist Interleukin Middle Aged Sulcus Receptor antagonist Gingivitis Interleukin 1 Receptor Antagonist Protein Cross-Sectional Studies Interleukin 1 receptor antagonist medicine.anatomical_structure Case-Control Studies Periodontics Female medicine.symptom business Interleukin-1 |
Zdroj: | Journal of Periodontal Research. 44:323-329 |
ISSN: | 1600-0765 0022-3484 |
DOI: | 10.1111/j.1600-0765.2008.01136.x |
Popis: | Background and Objective: While there is substantial information concerning the concentrations of interleukin-1 isoforms within gingival crevicular fluid, there is little information concerning their concentrations within either normal or diseased gingival tissues. Therefore, the aim of this study was to evaluate the relationship between the concentrations of gingival interleukin-1 isoforms and the adjacent sulcular depth. Material and Methods: Interdental gingival papillae were excised and grouped based on adjacent pocket depth and the presence of bleeding on probing. Gingiva adjacent to a sulcus of ≤ 3 mm without bleeding on probing were classified as ‘normal’; gingiva adjacent to a 3-mm sulcus with bleeding on probing were classified as ‘diseased-slight’; gingiva adjacent to a 4–6-mm sulcus featuring bleeding on probing were classified as ‘diseased-moderate’; and gingiva adjacent to a sulcus of > 6 mm featuring bleeding on probing were classified as ‘diseased-severe’. Tissues were solublized and the concentrations of interleukin-1β, interleukin-1α, interleukin-1 receptor antagonist and interleukin-6 were assessed by enzyme-linked immunosorbent assay. Data were compared by factorial analysis of variance, the post-hoc Tukey test and the Pearson’s correlation test. Results: Gingival concentrations of interleukin-6, interleukin-1 receptor antagonist, interleukin-1α- and interleukin-1β were significantly greater at diseased-severe sites than at normal, diseased-slight, or diseased-moderate sites (p |
Databáze: | OpenAIRE |
Externí odkaz: |