Apoptosis of smooth muscle cells is not silent: Fas/FADD initiates a program of inflammatory gene expression
| Autor: | Friedemann J. Schaub, Daniel F. Bowen-Pope |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Necrosis
Arteriosclerosis Fas-Associated Death Domain Protein Gene Expression Apoptosis Fas ligand Muscle Smooth Vascular In vivo medicine Animals Humans FADD Gene Chemokine CCL2 Adaptor Proteins Signal Transducing Inflammation biology Macrophages Interleukin-8 Fas receptor Cancer research biology.protein Blood Vessels medicine.symptom Cardiology and Cardiovascular Medicine Ligation Carrier Proteins Interleukin-1 |
| Zdroj: | Trends in cardiovascular medicine. 11(1) |
| ISSN: | 1050-1738 |
| Popis: | Unlike necrosis, apoptosis is classically considered to be “silent,” (i.e., self-contained and non-inflammatory). In this review, we describe the system that we developed to regulate apoptosis of smooth muscle cells (SMC) in vivo. We have used this system to demonstrate that SMC apoptosis initiated by FADD or by Fas ligation includes a specific program of expression of pro-inflammatory genes. We discuss how this conclusion can be reconciled with reports that Fas plays an anti-inflammatory role in vascular lesions. |
| Databáze: | OpenAIRE |
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