Synthesis of Ferrocenestrone: the First Metallocene Based Steroid Analogue
| Autor: | David Sedlák, Filip Hessler, Petr Bartůněk, Ivana Císařová, Martin Kotora |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular chemistry.chemical_classification Double bond Metallocenes Stereochemistry Organic Chemistry Enantioselective synthesis Stereoisomerism Chemistry Techniques Synthetic General Chemistry Crystallography X-Ray Enyne metathesis Catalysis chemistry.chemical_compound Ferrocene chemistry Intramolecular force Organometallic Compounds Side chain Moiety Steroids Ferrous Compounds Hydrogenation Metallocene |
| Zdroj: | Chemistry - A European Journal. 18:5515-5518 |
| ISSN: | 0947-6539 |
| DOI: | 10.1002/chem.201200687 |
| Popis: | Ferrocenestrone, the first steroid derivative containing a metallocene moiety, was stereoselectively prepared. The key steps included the enantioselective functionalization of ferrocene, elongation of the side chain, intramolecular enyne metathesis, Diels-Alder reaction, heterogeneous hydrogenation of the sterically hindered double bond, and finally inversion of the configuration at C13. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text