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Smagliy V. S., Gozhenko A. I., Korda I. V., Badiuk N. S., Zukow W., Kovbasnyuk M. M., Popovych I. L. VARIANTS OF URIC ACID METABOLISM AND THEIR IMMUNE AND MICROBIOTA ACCOMPANIMENTS IN PATIENTS WITH NEUROENDOCRINE-IMMUNE COMPLEX DYSFUNCTION. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2020;1(59):114-125. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.3744396 http://aptm.org.ua VARIANTS OF URIC ACID METABOLISM AND THEIR IMMUNE AND MICROBIOTA ACCOMPANIMENTS IN PATIENTS WITH NEUROENDOCRINE-IMMUNE COMPLEX DYSFUNCTION V. S. Smagliy1, A. I. Gozhenko1, I. V. Korda2, N. S. Badiuk1, W. Zukow3, M. M. Kovbasnyuk4, I. L. Popovych1,4 1Ukrainian Scientific Research Institute of Medicine for Transport, Odessa prof.gozhenko@gmail.com; badiuk_ns@ukr.net 2IY Horbachevs’kyi National Medical University, Ternopil’, kordai@tdmu.edu.ua 3Nicolaus Copernicus University, Torun, Poland zukow@umk.pl 4OO Bohomolets’ Institute of Physiology, Kyїv i.popovych@biph.kiev.ua Summary Background. Previously, we found a wide range of uric acid exchange parameters and functional relationships of uricemia and uricosuria with the parameters of immunity in healthy rats analyzed. We continued our research along the same lines in the clinical observation of patients, who came to the Truskavets’ spa for the rehabilitation treatment. Relationships between uricemia and uricosuria, on the one hand, and immunity and microbiota parameters, on the other hand, have been identified. The purpose of this study is to further explore these relationships using the cluster and discriminant analyses. Material and Methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the rehabilitation treatment of chronic pyelonephritis combined with cholecystitis in remission. The serum and daily urine levels of the uric acid by uricase method were determined. Immune status evaluated on a set of I and II levels recommended by the WHO. The condition of microbiota is evaluated on the results of sowing of feces and urine. Results. Cluster analysis revealed 4 variants of uric acid metabolism by deviating uricosuria and uricemia from the norm in Z-scores. In 34% of individuals, moderate hypouricosuria (-0,97±0,11 Z) is combined with a lower borderline uricemia (-0,53±0,20 Z). In 25% of patients, lower-border uricemia (-0,70±0,22 Z) is accompanied by marked hyperuricosuria (+3,87±0,25 Z). In 24% of people, moderately elevated uricosuria (+1,26±0,14 Z) is combined with completely normal uricemia (+0,09±0,16 Z). Finally, in 17%, a similar level of uricosuria (+1,17±0,19 Z) is combined with marked hypouricemia (-1,89±0,14 Z). Discriminant analysis revealed 12 parameters of immunity and 5 parameters of microbiota, by which the clusters of uric acid metabolism are identified with 94,3 %% accuracy. Conclusion. Endogenous uric acid has a modulating overall beneficial effect on a number of immune and microbiota parameters in both healthy rats and people with neuroendocrine-immune complex dysfunction on background of chronic inflammatory diseases. Keywords: Uricemia, Uricosuria, Immunity, Microbiota, Relationships, Humans. |
