A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial
| Autor: | Bianca da Silva Sufi, Lucas Idacir Sbrugnera Nazato, Giovana Padovani, Luiz Claudio Di Stasi, Lilian Mussi, Wagner Vidal Magalhães, Flávio Bueno de Camargo, Jeanifer Caverzan |
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| Přispěvatelé: | Chemyunion Química Ltda, Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2020 |
| Předmět: |
PPAR-γ
Facial rejuvenation Thymus vulgaris wrinkles Adipose tissue Stimulation Dermatology Pharmacology adipogenesis Thymus Plant 030207 dermatology & venereal diseases 03 medical and health sciences Mice 0302 clinical medicine Downregulation and upregulation Double-Blind Method facial rejuvenation Medicine Animals Adipogenesis Adiponectin biology business.industry Fibroblasts biology.organism_classification In vitro Skin Aging Basic-Leucine Zipper Transcription Factors thyme 030220 oncology & carcinogenesis Female business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1473-2165 |
| Popis: | Made available in DSpace on 2021-06-25T10:16:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Background: The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long-term application. Efforts to develop new topically active anti-aging products with fewer adverse effects are a huge challenge that should be faced. Aims: We evaluated the anti-aging effects of a phytocosmetic preparation containing Thymus vulgaris associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double-blind placebo-controlled clinical trial and in vitro cell culture assays. Methods: A clinical trial was conducted to evaluate the effects of ThymLec 2% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured-light Scanner. In the in vitro studies using 3T3-L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR-γ expression by RT-PCR analysis. Results: Topical treatment with ThymLec 2% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR-γ expression increasing adiponectin production and stimulating the adipogenesis process. Conclusions: The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti-aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR-γ expression and adiponectin production. Research and Development Department Chemyunion Química Ltda Laboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (Unesp) Laboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (Unesp) |
| Databáze: | OpenAIRE |
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