Predictors of Early Abstinence in Smokers With Schizophrenia
| Autor: | Nancy A. Rigotti, Donald C. Goff, Melissa A. Culhane, Ruth S. Barr, David A. Schoenfeld, A. Eden Evins, Thilo Deckersbach, Corinne Cather, Oliver Freudenreich |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Nicotine medicine.medical_specialty Multivariate analysis medicine.medical_treatment media_common.quotation_subject Administration Cutaneous Article Chewing Gum Pharmacotherapy Polymethacrylic Acids Internal medicine medicine Humans Attention Nicotinic Agonists Psychiatry media_common Cognitive Behavioral Therapy business.industry Abstinence medicine.disease Tobacco Use Cessation Devices United States Psychiatry and Mental health Logistic Models Schizophrenia Multivariate Analysis Cognitive therapy Smoking cessation Female Polyvinyls Schizophrenic Psychology Smoking Cessation business Diagnosis of schizophrenia medicine.drug |
| Zdroj: | The Journal of Clinical Psychiatry. 69:1743-1750 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.v69n1109 |
| Popis: | BACKGROUND In patients with schizophrenia, the smoking cessation rate is low and the burden of smoking-related morbidity and mortality is high. Identification of factors associated with abstinence may allow clinicians to optimize treatment prior to a smoking cessation attempt. METHOD To identify factors associated with successful smoking cessation in patients with a DSM-IV diagnosis of schizophrenia, we analyzed baseline data from 114 stable outpatient smokers with schizophrenia who participated in 1 of 2 smoking cessation trials. The outcome of interest was 4 weeks' continuous abstinence at the end of a 12-week nicotine dependence treatment intervention. Baseline factors associated with abstinence were identified with univariate methods and entered into a manual, forward-selection multivariable regression model to identify independent predictors of abstinence. The study was conducted from March 1999 to February 2004. RESULTS Fourteen of 114 participants (12%) had biochemically verified 4 weeks' continuous abstinence at week 12. We included 10 noncorrelated variables with a univariate association with abstinence in a multivariable model, controlling for pharmacotherapy, age, and gender. Age at initiation of smoking and baseline variability in attentiveness, as measured by Continuous Performance Test-AX (CPT-AX) hit reaction time standard error, were independently associated with abstinence. For every year increase in age at initiation of smoking, the OR for abstinence was 1.36 (95% CI = 1.01 to 1.83), p = .048. For every millisecond decrease in the variability of the reaction time of CPT-AX, the OR for achieving abstinence was 1.55 (95% CI = 1.07 to 2.24), p = .021. CONCLUSION Later initiation of smoking was associated with increased and baseline attentional impairment with reduced odds of abstinence. Additional research to further our understanding of the relationship between attentional impairment and cigarette smoking in schizophrenia may lead to improved nicotine dependence treatments for this group. |
| Databáze: | OpenAIRE |
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