Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle
| Autor: | Takuya Mori, Isao Kawahara, Kenji Kodama, Hirokazu Tanaka, Yukinori Taniguchi, Hiroyuki Kodama, Rina Fujiwara-Tani, Yi Luo, Yoshihiro Miyagawa, Kei Goto, Nobuyoshi Hosoito, Hiroki Kuniyasu |
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| Rok vydání: | 2018 |
| Předmět: |
Hyperthermia
Male Necrosis Iron Apoptosis Pathology and Forensic Medicine 03 medical and health sciences Mice 0302 clinical medicine Myosin medicine Alloys Autophagy Animals Muscle Skeletal Molecular Biology Mice Inbred BALB C Chemistry Magnetic Phenomena technology industry and agriculture Skeletal muscle Cell Biology General Medicine Hyperthermia Induced equipment and supplies medicine.disease Muscle atrophy Muscular Atrophy medicine.anatomical_structure Magnetic hyperthermia 030220 oncology & carcinogenesis Biophysics medicine.symptom 030215 immunology Aluminum |
| Zdroj: | Pathobiology : journal of immunopathology, molecular and cellular biology. 86(5-6) |
| ISSN: | 1423-0291 |
| Popis: | Necrosis-inducing anticancer drugs enhance high-mobility group box 1 (HMGB1) release during cell necrosis, and HMGB1-induced autophagy in skeletal muscle induces muscle atrophy. We evaluated the efficacy of magnetic hyperthermia therapy (MHT) using a low-energy magnetic field and self-controlled heating elements in tumor treatment. MHT-induced apoptosis by heating mouse subcutaneous tumors at 43°C using a heat-controlling iron-aluminum (Fe-Al) milling alloy. In contrast, MHT using Fe line-induced necrosis by heating to approximately 100°C. Furthermore, MHT with Fe-Al milling alloy reduced stemness. In hyperthermia using age line or Fe-Al milling alloy, both of them provided histological degeneration in skeletal muscle; however, qualitative differences were observed. MHT using Fe-line induced pronounced autophagy, decrease of myosin heavy chain content, and increase in serum HMGB1. In contrast, MHT using Fe-Al milling alloy induced heat shock protein 90 but no autophagy and decreased serum HMGB1. Therefore, MHT using Fe-Al milling alloy might be a good method for local treatment of tumors to reduce skeletal muscle atrophy. |
| Databáze: | OpenAIRE |
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