Increased endogenous carbon monoxide production in severe sepsis
| Autor: | Dominique Perrin, Rachid Zegdi, Michèle Burdin, Richard Boiteau, Alain Tenaillon |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Artificial ventilation medicine.medical_treatment Comorbidity Critical Care and Intensive Care Medicine Sepsis Excretion Intensive care medicine Humans Prospective Studies Prospective cohort study APACHE Aged Breath test Mechanical ventilation Analysis of Variance Carbon Monoxide Lung medicine.diagnostic_test business.industry medicine.disease Oxidative Stress medicine.anatomical_structure Breath Tests Case-Control Studies Anesthesia Female business |
| Zdroj: | Intensive Care Medicine. 28:793-796 |
| ISSN: | 1432-1238 0342-4642 |
| Popis: | Objective: A comparison was made between the endogenous carbon monoxide (CO) production in mechanically ventilated critically ill adult patients with, and those without, severe sepsis. Design: Prospective comparative study. Setting: Medical ICU in a community hospital. Patients: Twenty-four patients with severe sepsis of various etiologies and five control patients with varying diagnoses. Intervention: CO concentration was determined with an infrared CO analyzer on exhaled breath collected at the outlet of the ventilator. Endogenous CO production was estimated by the lung CO excretion rate measured at steady state. Measurements and main results: Endogenous CO production was higher in the sepsis group during the first 3 days of treatment in comparison to the control group (10.9±5 (SD) µl/kg per h on day 1, 7.8±4.9 µl/kg per h on day 2 and 6.9±4.7 µl/kg per h on day 3 versus 2.1±0.5 µl/kg per h; p |
| Databáze: | OpenAIRE |
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