The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease
| Autor: | Takuya Ishikawa, Eizaburo Ohno, Kenta Yamamoto, Yasuyuki Mizutani, Takashi Honda, Masanao Nakamura, Shun Hattori, Takeshi Yamamura, Masatoshi Ishigami, Tsunaki Sawada, Keiko Maeda, Mitsuhiro Fujishiro, Hiroki Kawashima, Kazuhiro Furukawa, Yoshiki Hirooka |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease Gut flora Gastroenterology Capsule Endoscopy Sensitivity and Specificity 03 medical and health sciences Feces Young Adult 0302 clinical medicine Crohn Disease Predictive Value of Tests Internal medicine Intestine Small Medicine Humans Microbiome Prospective Studies Intestinal Mucosa Prospective cohort study Aged Double-Balloon Enteroscopy Crohn's disease Wound Healing biology business.industry Area under the curve Hepatology Middle Aged medicine.disease biology.organism_classification Small intestine Gastrointestinal Microbiome medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female business Biomarkers |
| Zdroj: | Journal of gastroenterology. 55(12) |
| ISSN: | 1435-5922 |
| Popis: | Mucosal healing is the main treatment goal for Crohn’s disease. In this situation, some patients have difficulty with endoscopic evaluation of the entire small intestine. Crohn’s disease is closely associated with the gut microbiota, but the relationship between the microbiome and disease activity in the small intestine remains unclear. We examined the association between the microbiome and endoscopic findings in the small intestine and determined whether the microbiome can predict mucosal healing. The patients with Crohn’s disease who were scheduled for capsule or balloon-assisted endoscopy were included in this prospective study. Patients whose entire small intestine was evaluated were divided into two groups based on ulcerative findings. The microbiomes in the fecal samples were analyzed using 16S rRNA sequencing. The 38 enrolled patients were divided into the ulcer group (24) and mucosal healing group (14). The ulcer group exhibited lower α diversity. Six genera, namely Faecalibacterium (P = 0.008), Lachnospira (P = 0.009), Paraprevotella (P = 0.01), Dialister (P = 0.012), Streptococcus (P = 0.025), and Clostridium (P = 0.028) were enriched in the mucosal healing group. A predictive score for mucosal healing was defined using these six genera. The area under the curve was 0.795 and the sensitivity and specificity for predicting mucosal healing were 0.643 and 0.917, respectively. Fecal microbiome is corelated with disease activity in the entire small intestine in Crohn’s disease patients. The predictive score proposed by microbiota characteristics was a potential biomarker for mucosal healing in the small intestine. |
| Databáze: | OpenAIRE |
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