Lacrimal sac adenocarcinoma managed with androgen deprivation
| Autor: | Jasmine H. Francis, David H. Abramson, Noa Biran, Julia Fallon, Korey Jaben, William Oh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Case Report Androgen deprivation therapy 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology medicine Lymph node Lacrimal sac adenocarcinoma medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease Androgen Lacrimal sac Androgen receptor Ophthalmology medicine.anatomical_structure Positron emission tomography lcsh:RE1-994 030221 ophthalmology & optometry Adenocarcinoma Radiology business 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Ophthalmology Case Reports, Vol 19, Iss, Pp 100607-(2020) American Journal of Ophthalmology Case Reports |
| ISSN: | 2451-9936 |
| Popis: | Purpose To describe a case of primary lacrimal sac adenocarcinoma treated primarily with androgen deprivation therapy (ADT) with good clinic response. Observations An 82-year-old male presented with a painless right orbital mass. Pathology following partial resection was consistent with primary lacrimal sac adenocarcinoma positive for androgen receptors (AR). Magnetic resonance imaging (MRI) scan showed an orbital mass with extension into the nasolacrimal apparatus and intraconally between the medial and inferior recti. Staging positron emission tomography/computed tomography (PET/CT) showed one hypermetabolic right sided lymph node in addition to the known orbital mass. Orbital exenteration and external beam radiation therapy were offered as the primary treatment modality however the patient refused. He subsequently received four years of androgen deprivation monotherapy, before stopping due to sexual side effects, with no progression of local or metastatic disease and some local regression documented on MRI at 5 years. Conclusions and Importance Lacrimal sac adenocarcinoma is commonly found to be AR positive on pathology. Our case shows that ADT can serve as an effective treatment modality for those patients that defer primary surgical management. |
| Databáze: | OpenAIRE |
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