The predisposing factors of AKI for prophylactic strategies in burn care
| Autor: | Cheng-Jui Lin, Fang-Ju Sun, Xiaofeng Jia, Shin-Yi Tsai, Chien-Feng Kuo, Chon-Fu Lio, Yu-Tien Chen, Chia-Meng Yu, Shou-Chuan Shih |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Burn injury Emergency and Critical Care lcsh:Medicine Abbreviated Burn Severity Index score General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences 0302 clinical medicine law Internal Medicine Medicine Parkland formula America Burn Association (ABA) sepsis criteria business.industry General Neuroscience Mortality rate Incidence (epidemiology) Health Policy lcsh:R Acute kidney injury 030208 emergency & critical care medicine General Medicine medicine.disease Intensive care unit Kidney Disease: Improving Global Outcomes (KDIGO) criteria 030220 oncology & carcinogenesis Emergency medicine Cohort Public Health General Agricultural and Biological Sciences business ABSI score Kidney disease Translational Medicine |
| Zdroj: | PeerJ PeerJ, Vol 8, p e9984 (2020) |
| ISSN: | 2167-8359 |
| Popis: | Background Acute kidney injury (AKI) is one of the most severe complications of burn injury. AKI with severe burn injury causes high mortality. This study aims to investigate the incidence of and predisposing factors for AKI in burn patients. Methods This is a single-center, retrospective, descriptive criterion standard study conducted from June 27, 2015, to March 8, 2016. We used Kidney Disease Improving Global Outcomes criteria to define and select patients with AKI. The study was conducted by recruiting in hospital patients who suffered from the flammable cornstarch-based powder explosion and were treated under primary care procedures. A total of 49 patients who suffered from flammable dust explosion-related burn injury were enrolled and admitted on June 27, 2015. The patients with more than 20% total body surface area of burn were transferred to the intensive care unit. Patients received fluid resuscitation in the first 24 hours based on the Parkland formula. The primary measurements were the incidence of and predisposing factors for AKI in these patients. Demographic characteristics, laboratory data, and inpatient outcomes were also evaluated. The incidence of AKI in this cohort was 61.2% (n = 30). The mortality rate was 2.0% (n = 1) during a 59-day follow-up period. The multivariate analysis revealed inhalation injury (adjusted OR = 22.0; 95% CI [1.4–358.2]) and meeting ≥3 American Burn Association (ABA) sepsis criteria (adjusted OR = 13.7; 95% CI [1.7–110.5]) as independent risk factors for early advanced AKI. Conclusions The incidence rate of AKI was higher in this cohort than in previous studies, possibly due to the flammable dust explosion-related burn injury. However, the mortality was lower than that expected. In clinical practice, indicators of inflammation, including ABA sepsis criteria may help in predicting the risk of AKI in patients with burn injury. |
| Databáze: | OpenAIRE |
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