Liver size and indices of drug metabolism in epileptics
| Autor: | JT Ahokas, U. Pitkänen, Eero A. Sotaniemi, HI Pirttiaho |
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| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Cytochrome Pharmacology Cytochrome P-450 Enzyme System In vivo Internal medicine Biopsy medicine Humans Pharmacology (medical) In patient Liver size Epilepsy biology medicine.diagnostic_test Organ Size Middle Aged In vitro Kinetics Endocrinology Liver Pharmaceutical Preparations Liver biopsy biology.protein Female Antipyrine Drug metabolism Research Article |
| Zdroj: | British Journal of Clinical Pharmacology. 6:273-278 |
| ISSN: | 0306-5251 |
| Popis: | 1 The relationship between liver size and in vivo (antipyrine kinetics) and in vitro (cytochrome P-450) drug metabolism was investigated in twenty-one epileptics on long-term anticonvulsant therapy and in controls. 2 The epileptics exhibited significant enlargement of the liver and enhancement of drug metabolism compared to the controls. 3 Liver size correlated to antipyrine kinetics only in controls. Concentration of cytochrome P-450 in liver biopsy specimens correlated with liver size neither in controls nor in epileptics. 4 The total hepatic cytochrome P-450, estimated on the basis of liver weight and cytochrome P-450 concentration of biopsy samples, correlated linearly with antipyrine kinetics, except in patients with the most severely disturbed liver architecture. 5 Measurement of liver size is essential when comparing in vivo and in vitro drug metabolism, but the changes in liver histology are also of great importance. |
| Databáze: | OpenAIRE |
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