Coagulation effects of cyclosporine in liver transplantation
| Autor: | Charles R. Spillert, Dorian Wilson, Eric J. Lazaro, R. J. Ferrante |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Allergy medicine.medical_treatment Immunology Liver transplantation Toxicology Gastroenterology Internal medicine Escherichia coli medicine Humans Pharmacology (medical) Blood Coagulation Saline Blood coagulation test Whole blood Pharmacology Chemotherapy business.industry medicine.disease Liver Transplantation Endotoxins Transplantation Coagulation Cyclosporine Blood Coagulation Tests business |
| Zdroj: | Agents and Actions. 39:C102-C103 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01972734 |
| Popis: | Thromboembolic complications have been described in graft recipients receiving cyclosporine (CS). Whether these individuals have a hypercoagulable state when compared to healthy controls was evaluated. Recalcification times (RT) of saline-incubated citrated whole blood and endotoxin-incubated whole blood of both control and transplant patients were determined. There was no difference between the RT saline or RT endotoxin groups in both patient groups. These data suggest that CS alone has no procoagulant effects, but that additional factors such as endotoxin and/or graft-induced antigen production may provoke the thrombotic complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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