Long-term Consequences of239PuO2Exposure in Dogs: Persistent T Lymphocyte Dysfunction
| Autor: | D. S. Swafford, B.A. Muggenburg, Raymond A. Guilmette, David E. Bice, Patrick J. Haley, D.R. Davila |
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| Rok vydání: | 1992 |
| Předmět: |
Aging
medicine.medical_specialty Time Factors T-Lymphocytes Lymphocyte Biology Lymphocyte Activation Beagle Dogs Immune system Internal medicine Administration Inhalation medicine Animals Radiology Nuclear Medicine and imaging Phytohaemagglutinin Aerosols Immunity Cellular Radiological and Ultrasound Technology Inhalation T lymphocyte Plutonium Middle age medicine.anatomical_structure Endocrinology Ageing biology.protein |
| Zdroj: | International Journal of Radiation Biology. 61:123-133 |
| ISSN: | 1362-3095 0955-3002 |
| Popis: | Young Beagle dogs were exposed by inhalation to aerosols of 239PuO2 and observed for their lifespans as part of a large, ongoing study of the biological effects of inhaled radionuclides. The purpose of our study was to compare certain immune responses of the 239PuO2-exposed dogs at middle age (7-10 years old) and old age (12-14 years old), with those of unexposed, age-matched or young (3-4 years old) animals. Some of the aged, exposed dogs had developed lung tumours. Lymphocyte proliferative responses to phytohaemagglutinin (PHA) were lower in aged control dogs than in either young or middle-aged control dogs. Both aged and middle-aged, radiation-exposed dogs had decreased responses to PHA when compared to age-matched controls. Responses to concanavalin A (Con A) were not affected by age in control dogs, but tended to decrease in the oldest group of radiation-exposed dogs. Responses to both PHA and Con A were severely depressed in tumour-bearing dogs. The cytolytic activity of natural killer cells was not affected by age, radiation exposure, or tumour presence. We concluded that inhalation of 239PuO2 by young Beagle dogs resulted in an earlier-than-normal decrease in the ability of T cells to respond to mitogenic stimulation. In other words the depressed responses to PHA that were observed might represent radiation-induced, accelerated ageing of the T cell response. |
| Databáze: | OpenAIRE |
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