Cord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort
| Autor: | Anna Łuczyńska, Ben Schöttker, Magdeldin Elgizouli, Hermann Brenner, Chad A. Logan, Alexandra Nieters, Dietrich Rothenbacher |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Epidemiology Mothers vitamin D deficiency Immunoenzyme Techniques Risk Factors Germany Lower respiratory tract infection Prevalence medicine Vitamin D and neurology Humans Prospective Studies Vitamin D Child Prospective cohort study Respiratory Tract Infections Respiratory tract infections business.industry Infant Vitamins Fetal Blood Vitamin D Deficiency medicine.disease Confidence interval Logistic Models Child Preschool Population Surveillance Relative risk Female Seasons business |
| Zdroj: | European Journal of Epidemiology. 29:585-594 |
| ISSN: | 1573-7284 0393-2990 |
| Popis: | Lower respiratory tract infections (LRTIs) are a major cause of hospitalization in infants. Research suggests that immunomodulatory properties of vitamin D may influence LRTI risk. This study's objective was to examine whether 25-hydroxyvitamin D [25(OH)D] concentrations in cord blood influenced susceptibility to LRTI in the first year of life. Data was analyzed from a prospective birth cohort of 777 mother-infant pairs based in Ulm, Germany. Relative risks (RRs) of LRTI in relation to 25(OH)D cord blood levels were estimated by log-binomial regression after adjustment for potential confounders. To account for seasonal variation in both vitamin D levels and infections, we examined the association in different seasons. Analyses were conducted using clinical predefined cutpoints, quartiles, and season-standardized 25(OH)D quartiles. We observed a statistically significant association between 25(OH)D status in cord blood and risk of LRTI across the year using clinical cutpoints. The adjusted RR of LRTI for individuals with vitamin D deficiency (25 nmol/L) in comparison to the referent category (50 nmol/L) was 1.32 [95 % confidence interval (CI) 1.00, 1.73]. The association differed by maternal allergy status; children born to mothers without allergy demonstrated a RR of 1.45 (95 % CI 1.03, 2.03). The effect was largely driven by a strong association between 25(OH)D and LRTI in infants born in fall with a RR of 3.07 (95 % CI 1.37, 6.87). Our findings suggest that vitamin D deficiency at birth is associated with increased risk of LRTI particularly in infants born to mothers without allergy. The association seems strongest in infants born in fall. |
| Databáze: | OpenAIRE |
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