Lung function: population epidemiology and concordance in Australian children aged 11–12 years and their parents
| Autor: | Anneke Grobler, Melissa Wake, Tahmeed Raheem, Liam Welsh, Sarath Ranganathan, Gayan Kathriachchige |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Spirometry
Adult Male Parents Vital capacity Cross-sectional study Concordance Population spirometry Vital Capacity Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine children Forced Expiratory Volume medicine epidemiologic studies Childcheckpoint Series Humans Lung volumes 030212 general & internal medicine Longitudinal Studies education Child Lung education.field_of_study medicine.diagnostic_test business.industry Research inheritance patterns Australia lung function General Medicine reference values Middle Aged Respiratory Function Tests Cross-Sectional Studies 030228 respiratory system Multivariate Analysis Linear Models Female business Demography |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesTo describe the epidemiology of lung function in Australian children aged 11–12 years and their parents, and explore the degree of intergenerational concordance.DesignCross-sectional study (the Child Health CheckPoint) nested in the Longitudinal Study of Australian Children (LSAC).SettingAssessment centres in seven Australian cities and eight regional towns, February 2015 to March 2016. Families unable to attend a clinic appointment were offered a home visit during the same period.Participants1874 families (53% of all eligible) participated in the study. Lung function data were available for 1759 children aged 11–12 years and 1774 parents (1668 biological pairs).Outcome measuresParticipants completed spirometry with measures including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid expiratory flow (MEF), converted to z-scores using Global Lung Initiative equations. Parent–child concordance was assessed using Pearson’s correlation coefficients and multivariable linear regression models. Survey weights and methods accounted for LSAC’s complex sampling, stratification and clustering within postcodes.ResultsAll lung function measures followed approximately normal distributions. Mean (SD) for FEV1, FVC and MEF z-scores in children were 0.33 (1.07), 0.83 (1.14) and −0.48 (1.09), respectively. Mean (SD) in parents were 0.28 (1.10), 0.85 (1.15) and −0.45 (1.10), respectively. Parent FEV1, FVC and MEF were associated with child lung function with significant positive correlation coefficients (0.22, 95% CI 0.17 to 0.26; 0.24, 95% CI 0.20 to 0.29; and 0.24, 95% CI 0.20 to 0.29, respectively).ConclusionsMean lung volumes were larger but with smaller airway size than international standards for both parents and children in this population sample. Modest associations between parent and child lung function highlight the potential for better identification of ‘at risk’ populations. Therefore, these findings may aid the development of health policy that aims to prevent the onset or limit the progression of lung disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|