Proteinuria during dengue fever in children
| Autor: | Anavaj Sakuntabhai, Veasna Duong, Anne-Claire Andries, Sowath Ly, Arnaud Tarantola, Paul F. Horwood, Julien Cappelle, Alexandra Kerleguer, Philippe Dussart, Sivuth Ong, Philippe Buchy |
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| Přispěvatelé: | Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Animal et gestion intégrée des risques (UPR AGIRs), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Réseau International des Instituts Pasteur (RIIP), Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), GlaxoSmithKline, Glaxo Smith Kline, The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007/2011) under Grant Agreement n° 282 378, European Project: 282378,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,DENFREE(2012), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Urine Disease MESH: Dengue MESH: Hospitalization L73 - Maladies des animaux urologic and male genital diseases Dengue fever Dengue dipstick chemistry.chemical_compound 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child Prospective Studies 030212 general & internal medicine Child Prospective cohort study Créatinine Proteinuria biology 000 - Autres thèmes General Medicine UPCR urine 3. Good health Hospitalization Flavivirus Infectious Diseases Area Under Curve Creatinine Female medicine.symptom Cambodia Infection urine electrophoresis Enfant Microbiology (medical) medicine.medical_specialty MESH: Creatinine lcsh:Infectious and parasitic diseases 03 medical and health sciences MESH: Proteinuria Internal medicine medicine Humans lcsh:RC109-216 Diagnostic MESH: Humans Protéinurie business.industry MESH: Cambodia Dipstick medicine.disease biology.organism_classification MESH: Prospective Studies MESH: Male Surgery 030104 developmental biology chemistry Électrophorèse MESH: Biomarkers MESH: Area Under Curve U30 - Méthodes de recherche proteinuria business MESH: Female Biomarkers |
| Zdroj: | International Journal of Infectious Diseases, Vol 55, Iss C, Pp 38-44 (2017) International Journal of Infectious Diseases International Journal of Infectious Diseases, 2017, 55, pp.38-44. ⟨10.1016/j.ijid.2016.12.022⟩ International Journal of Infectious Diseases, Elsevier, 2017, 55, pp.38-44. ⟨10.1016/j.ijid.2016.12.022⟩ |
| ISSN: | 1878-3511 1201-9712 |
| Popis: | International audience; OBJECTIVES:This study aimed to investigate proteinuria occurring during dengue disease in children and assess if measurement of this parameter can help physicians in the clinical management of patients.METHODS:Proteinuria was assessed by dipstick and quantified by urine protein:creatinine ratio (UPCR) in samples from patients hospitalized with a confirmed dengue infection and in healthy controls.RESULTS:The dipstick tested positive in 42.9% of the patients presenting at hospital with dengue versus 20.0% in healthy controls. UPCR increased during the critical phase of the disease; peaking one week after fever onset then decreasing as the patients recovered. Patients with warnings signs or severe dengue were more likely to present with proteinuria detected by UPCR at the time of hospital admission compared to patients without warning signs. The sensitivity of this marker, however, was limited as only 16.1% of the patients with warning signs had proteinuria.CONCLUSIONS:Urine dipstick and UPCR do not seem to be very valuable for the triage of the patients at the time of the initial consultation but the observation of a decrease of the UPCR during the course of the illness appears to indicate an evolution towards recovery. |
| Databáze: | OpenAIRE |
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