Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum
| Autor: | Luca Fésűs, Norbert Wikonkál, Tamas Aranyi, Alexey Lihachev, Pálma Anker, Dóra Plázár, Sara Zakarias, András Bánvölgyi, Norbert Kiss, Márta Medvecz, Marta Lange, Szabolcs Bozsányi, Ilze Lihacova, K. Farkas |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Diagnostic methods diagnosis Uninvolved skin Clinical Biochemistry 01 natural sciences Article autofluorescence imaging calcification 010309 optics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine diffuse reflectance imaging 0103 physical sciences medicine pseudoxanthoma elasticum Skin manifestations lcsh:R5-920 quantitative analysis integumentary system business.industry LED Non invasive medicine.disease Pseudoxanthoma elasticum Connective tissue disease Autofluorescence dermoscopy lcsh:Medicine (General) business Calcification |
| Zdroj: | Diagnostics, Vol 11, Iss 260, p 260 (2021) Diagnostics Volume 11 Issue 2 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11020260 |
| Popis: | Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximum AF intensity values were found in areas of PXE-affected skin when compared to uninvolved skin. Conversely, images acquired with the use of 660 and 940 nm illumination showed no mentionable difference. Our results demonstrate that AF imaging may be used in the in vivo diagnostics and quantification of the severity of the skin lesions of PXE patients. In addition, it is a safe, fast and cost-effective diagnostic method. AF imaging may be also used to objectively monitor the efficacy of the possible novel therapeutic approaches of PXE in the future. |
| Databáze: | OpenAIRE |
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