Nanomedicine for the Treatment of Rheumatoid Arthritis

Autor: Moonkyoung Jeong, Ji-Ho Park
Rok vydání: 2020
Předmět:
musculoskeletal diseases
Surface Properties
Drug Compounding
Injections
Subcutaneous
Administration
Oral
Pharmaceutical Science
02 engineering and technology
Gastrointestinal system
Bioinformatics
030226 pharmacology & pharmacy
Injections
Intra-Articular
Arthritis
Rheumatoid
03 medical and health sciences
0302 clinical medicine
Adjuvants
Immunologic
Drug Discovery
medicine
Animals
Humans
Immunologic Factors
Particle Size
Therapeutic strategy
Autoimmune disease
Drug Carriers
business.industry
Anti-Inflammatory Agents
Non-Steroidal
Synovial Membrane
Immune modulation
021001 nanoscience & nanotechnology
medicine.disease
Arthritis
Experimental
Drug Liberation
Inflamed joints
Antirheumatic Agents
Delayed-Action Preparations
Rheumatoid arthritis
Injections
Intravenous
Nanoparticles
Molecular Medicine
Nanomedicine
0210 nano-technology
Antirheumatic drugs
business
Zdroj: Molecular Pharmaceutics. 18:539-549
ISSN: 1543-8392
1543-8384
DOI: 10.1021/acs.molpharmaceut.0c00295
Popis: Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in severe inflammatory microenvironments in the joint tissues. In clinics, disease-modifying antirheumatic drugs (DMARDs) are generally prescribed to patients with RA, but their long-term use often shows toxicity in some organs such as the gastrointestinal system, skin, and kidneys and immunosuppression-mediated infection. Nanomedicine has emerged as a new therapeutic strategy to efficiently localize the drugs in inflamed joints for the treatment of RA. In this Review, we introduce recent research in the area of nanomedicine for the treatment of RA and discuss how the nanomedicine can be used to deliver therapeutic agents to the inflamed joints and manage the progression of RA, particularly focusing on targeted delivery, controlled drug release, and immune modulation.
Databáze: OpenAIRE
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