Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model
| Autor: | Alper Çiftci, Şevki Güler, Gonca Çayır Keleș, Burcu Ozkan Cetinkaya, Bulent Ayas, Sevda Kurt, Çağla Gül Gürkan |
|---|---|
| Přispěvatelé: | BAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı, Güler, Şevki, OMÜ |
| Rok vydání: | 2019 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Histology animal structures Herbal Medicine medicine.medical_treatment Alveolar Bone Loss Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glucosides Internal medicine medicine Animals Rats Wistar Periodontitis General Dentistry Saline Dental alveolus Experimental Periodontitis business.industry 030206 dentistry medicine.disease Paeoniflorin Rats Resorption Vascular endothelial growth factor Clinical attachment loss chemistry Monoterpenes business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Oral Science. 61:554-557 |
| ISSN: | 1880-4926 1343-4934 |
| Popis: | WOS: 000509391800015 PubMed: 31588098 The purpose of this study was to evaluate the effects of administered Paeoniflorin (Pae) on periodontal tissues within an experimental periodontitis model. Forty male Wistar rats were used in this study and experimental periodontitis was created in all rats except in the control group (n = 10, first group). In the periodontitis group, experimental periodontitis was created but no other application was performed (n = 10, second group). In the other groups created experimental periodontitis, systemic Pae (n = 10, third group) or saline (n = 10, fourth group) was applied. A biochemical analysis of the gingival vascular endothelial growth factor (VEGF) levels and a histomorphometric analysis (measurements of the area of alveolar bone, alveolar bone resorption, and attachment loss) were performed. In the Pae group, the area of the alveolar bone was increased, while alveolar bone resorption and attachment loss decreased. Gingival VEGF levels increased in all groups that created experimental periodontitis and the greatest increase seen in the Pae group. Histomorphometric and biochemical analyses in this study suggest that Pae has a curative effect on periodontal tissues. However, additional studies are needed to confirm these results. Scientific Research Fund of Ondokuz Mayis University in Samsun/TurkeyOndokuz Mayis University [PYO.DIS.1904.15.001] This study was supported by the Scientific Research Fund of Ondokuz Mayis University in Samsun/Turkey (Project number: PYO.DIS.1904.15.001). |
| Databáze: | OpenAIRE |
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