Chlorpyrifos and other pesticide exposure and suspected developmental delay in children aged under 5 years: a case-control study in Phitsanulok, Thailand

Autor: Varintorn Pumyim, Uraiwan Chaichanawirote, Punaphop Chairattanasakda, Chudchawal Juntarawijit, Paphada Rakmeesri, Yuwayong Juntarawijit
Rok vydání: 2021
Předmět:
viruses
Developmental disorder
pesticides neurotoxicity
Methomyl
010501 environmental sciences
01 natural sciences
General Biochemistry
Genetics and Molecular Biology
chemistry.chemical_compound
03 medical and health sciences
0302 clinical medicine
Pregnancy
Environmental health
Parathion methyl
Medicine
Humans
030212 general & internal medicine
Pesticides
General Pharmacology
Toxicology and Pharmaceutics
child developmental delay
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
General Immunology and Microbiology
business.industry
neurodevelopmental toxicity
Methamidophos
Case-control study
Pregnancy Outcome
virus diseases
Articles
Odds ratio
General Medicine
Pesticide
biochemical phenomena
metabolism
and nutrition
medicine.disease
Thailand
digestive system diseases
chemistry
Chlorpyrifos
Case-Control Studies
Child
Preschool
Female
business
Research Article
Zdroj: F1000Research
ISSN: 2046-1402
DOI: 10.12688/f1000research.27874.2
Popis: Background: Developmental delay among children under 5 years of age is a serious global public health problem and much research has been carried out to find potential causes. Pesticides - especially organophosphates - are suspected to be one of the main causes of the problem. This study aimed to investigate the association between pesticide use by the mother during pregnancy and preschool children development using a case-control study.Methods: Data on prenatal and postnatal pesticide exposure of 442 children with suspected developmental delay, and 413 controls with normal development were included for analysis. The children were matched for gender, age, and residency. Data on pesticide exposure were collected via interview with the mother, and data on pregnancy outcomes abstracted from hospital records. Results: Chlorpyrifos exposure significantly increased the risk of developmental delay with an odds ratio (OR) of 3.71 (95% CI 1.03-13.36) for ever use of the pesticide, and an OR of 5.92 (95% CI 1.01-34.68) for postnatal exposure (p Conclusions: This case-control study found that chlorpyrifos and some other pesticides exposure during pregnancy were positively associated with developmental delay in children aged under 5 years. Further research should be conducted to better understand this potential effects of pesticides on child neurodevelopment, and the public - especially those who plan to have families - should be informed.
Databáze: OpenAIRE
Externí odkaz: