Human germinal center T cells are unique Th cells with high propensity for apoptosis induction
| Autor: | Shuhua Han, Biao Zheng, Ekaterina Marinova |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
CD40
Immunology Receptors Antigen T-Cell CD1 Apoptosis T-Lymphocytes Helper-Inducer Thymus Gland General Medicine Biology Germinal Center Natural killer T cell Cell biology Interleukin 21 CD57 Antigens Caspases biology.protein Humans Leukocyte Common Antigens Immunology and Allergy Cytotoxic T cell fas Receptor IL-2 receptor Antigen-presenting cell Interleukin 3 |
| Zdroj: | International Immunology. 18:1337-1345 |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/dxl066 |
| Popis: | Collaborative interactions between T(h) cells and B cells are necessary for the production of antibody responses to most protein antigens and for the generation of memory B cells in germinal centers (GCs). Although it is well established that T(h) cells are pivotal for the GC reaction, the mechanisms that control the homeostasis of T(h) cells during the GC response remain largely unknown. Here we show that, unlike other effector T cells, a significant number of CD4(+)CD45RO(+)CD57(+) T cells, which are the major T(h) cells residing in the GCs, are undergoing apoptosis in vivo. CD4(+)CD45RO(+)CD57(+) GC T cells exhibit similar sensitivities to apoptotic signals and to caspase inhibitors as immature thymocytes. Moreover, CD4(+)CD45RO(+)CD57(+) GC T cells express a unique profile of genes that control apoptosis and cell cycle, providing possible molecular mechanisms for the high rates of apoptotic death of these T(h) cells in the GCs. |
| Databáze: | OpenAIRE |
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