Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus
| Autor: | Trovato Ba, Di Fazio I, Mariano Malaguarnera, Romeo Ma, S Restuccia, Laurino A |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Hepatitis C virus Inflammation medicine.disease_cause Surgical oncology Internal medicine medicine Humans Interleukin 6 Hepatitis Chronic Hepatitis biology Interleukin-6 business.industry Gastroenterology Hepatitis C Middle Aged Hepatology medicine.disease Cytokine Liver Case-Control Studies Immunology biology.protein RNA Viral Female medicine.symptom business |
| Zdroj: | Journal of Gastroenterology. 32:211-215 |
| ISSN: | 1435-5922 0944-1174 |
| Popis: | Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and non-lymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virus-induced inflammatory state. |
| Databáze: | OpenAIRE |
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