Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

Autor: C.J. Thut, David Cosman, T. VandeBos, P.B. Delaney, S.D. Gimpel, Julie King, David P. Gearing, V. Price, M.P. Beckmann
Rok vydání: 1991
Předmět:
endocrine system
Leukemia Inhibitory Factor Receptor alpha Subunit
Receptors
OSM-LIF
Transcription
Genetic
Molecular Sequence Data
Restriction Mapping
Leukemia inhibitory factor receptor
Biology
Leukemia Inhibitory Factor
Polymerase Chain Reaction
General Biochemistry
Genetics and Molecular Biology
Substrate Specificity
Mice
Antigens
CD
Sequence Homology
Nucleic Acid
Enzyme-linked receptor
Cytokine Receptor gp130
Animals
Humans
Amino Acid Sequence
RNA
Messenger
Receptors
Cytokine
Receptors
Immunologic
Receptor
Molecular Biology
reproductive and urinary physiology
Lymphokines
Membrane Glycoproteins
General Immunology and Microbiology
Base Sequence
Interleukin-6
General Neuroscience
DNA
Glycoprotein 130
Blotting
Northern
Molecular biology
biological factors
Growth Inhibitors
Interleukin-21 receptor
embryonic structures
Electrophoresis
Polyacrylamide Gel
Signal transduction
Leukemia inhibitory factor
hormones
hormone substitutes
and hormone antagonists
Signal Transduction
Research Article
Zdroj: The EMBO journal. 10(10)
ISSN: 0261-4189
Popis: Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.
Databáze: OpenAIRE
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