Lipid profile pattern in pediatric overweight population with or without NAFLD in relation to IDF criteria for metabolic syndrome: a preliminary study
| Autor: | Florin Brezan, Beata Acs, Valentina Daniela Comanici, Paul Bălănescu, Tatiana Ciomârtan, Iustina Violeta Stan, Laura Prisăcariu, Anca Bălănescu, Ioan Gherghina |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male obesity Pediatric Obesity medicine.medical_specialty Adolescent Population 030209 endocrinology & metabolism idf consensus criteria Type 2 diabetes nafld Overweight 03 medical and health sciences 0302 clinical medicine Liver Function Tests Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Child education Triglycerides Ultrasonography Glycemic Metabolic Syndrome education.field_of_study Anthropometry medicine.diagnostic_test business.industry dyslipidemia Fatty liver nutritional and metabolic diseases medicine.disease RC31-1245 Lipids Blood Cell Count Cross-Sectional Studies Liver Child Preschool Female 030211 gastroenterology & hepatology medicine.symptom Metabolic syndrome Lipid profile business pediatric population Dyslipidemia |
| Zdroj: | Romanian Journal of Internal Medicine, Vol 56, Iss 1, Pp 47-54 (2018) |
| ISSN: | 2501-062X |
| DOI: | 10.1515/rjim-2017-0040 |
| Popis: | Background and aims. The aim of this study is to assess the lipid profile pattern of pediatric overweight and/or obese patients with Non-Alcoholic Fatty Liver Disease (NAFLD) in relation to IDF Consensus Criteria for Metabolic Syndrome (MetS). Material and Methods. We conducted a cross-sectional preliminary study on 45 consecutive pediatric patients. Overweight or obese children aged from 3 to 18 years were included. Standardized measurement of blood pressure and anthropometric parameters were performed. Biological evaluation included inflammatory status, lipid profile, glycemic profile, full blood count and liver function tests. Abdominal ultrasound was performed in all patients. Results. Prevalence of MetS was 44.4%. A number of 21 patients (46.7%) had NAFLD. MetS patients had higher risk for NAFLD (OR = 9.5, 95% CI = 2.42-37.24). Also patients with positive familial history of type 2 diabetes had a 6.61 fold higher risk for NAFLD (OR = 6.61, 95% CI = 1.74-25.1). We performed a subgroup analysis in patients under ten years old. Patients under the age of ten which had both NAFLD and MetS met more frequently the hypertriglyceride criterion. After adjusting for age and MetS presence, triglyceride levels independently associated with NAFLD (adjusted R square = 0.46, unstandardized B coefficient = 34.51, 95% CI = 4.01-65.02, p = 0.02). Conclusion. NAFLD obese patients had higher prevalence of MetS, higher BMI and particular lipid profile pattern. Triglyceride levels independently associated with NAFLD after adjusting for age and MetS presence. According to our findings we suggest early triglyceride testing (even below the age of ten) in selected patients. |
| Databáze: | OpenAIRE |
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