Synthetic Methylotrophy: A Practical Solution for Methanol-Based Biomanufacturing
| Autor: | Liwen Fan, Jibin Sun, Ping Zheng, Yu Wang, Philibert Tuyishime |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Bioengineering 02 engineering and technology Raw material 03 medical and health sciences chemistry.chemical_compound Bioreactors Natural gas Carbon source Biomanufacturing business.industry Methanol Assimilation (biology) Limiting 021001 nanoscience & nanotechnology Bioproduction Carbon 030104 developmental biology chemistry Metabolic Engineering Environmental science Biochemical engineering Microorganisms Genetically-Modified 0210 nano-technology business Biotechnology |
| Zdroj: | Trends in biotechnology. 38(6) |
| ISSN: | 1879-3096 |
| Popis: | The increasing availability and affordability of natural gas has renewed interest in using methanol for bioproduction of useful chemicals. Engineering synthetic methylotrophy based on natural or artificial methanol assimilation pathways and genetically tractable platform microorganisms for methanol-based biomanufacturing is drawing particular attention. Recently, intensive efforts have been devoted to demonstrating the feasibility and improving the efficiency of synthetic methylotrophy. Various fuel, bulk, and fine chemicals have been synthesized using methanol as a feedstock. However, fully synthetic methylotrophs utilizing methanol as the sole carbon source and commercially viable bioproduction from methanol remain to be developed. Here, we review ongoing efforts to identify limiting factors, optimize synthetic methylotrophs, and implement methanol-based biomanufacturing. Future challenges and prospects are also discussed. |
| Databáze: | OpenAIRE |
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