Alzheimer Disease Pathology in Subjects Without Dementia in 2 Studies of Aging: The Nun Study and the Adult Changes in Thought Study
| Autor: | Maryam Kherad Pezhouh, Suzanne L. Tyas, Peter T. Nelson, Karen S. SantaCruz, Joshua A. Sonnen, Mark F. Desrosiers |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Brain damage Neuropsychological Tests Statistics Nonparametric Article Pathology and Forensic Medicine Cellular and Molecular Neuroscience Apolipoproteins E Alzheimer Disease mental disorders medicine Humans Dementia Longitudinal Studies Cognitive decline Aged Retrospective Studies Cognitive reserve Aged 80 and over Brain Neurofibrillary Tangles Cognition General Medicine medicine.disease Nun Study Neurology Female Lewy Bodies Neurology (clinical) medicine.symptom Alzheimer's disease Cognition Disorders Psychology Braak staging |
| Zdroj: | Journal of Neuropathology & Experimental Neurology. 70:832-840 |
| ISSN: | 1554-6578 0022-3069 |
| DOI: | 10.1097/nen.0b013e31822e8ae9 |
| Popis: | Individuals with antemortem preservation of cognition who show autopsy evidence of at least moderate Alzheimer disease (AD) pathology suggest the possibility of brain reserve, that is, functional resistance to structural brain damage. This reserve would, however, only be relevant if the pathologic markers correlate well with dementia. Using data from the Nun Study (n = 498) and the Adult Changes in Thought (ACT) Study (n = 323), we show that Braak staging correlates strongly with dementia status. Moreover, participants with severe (Braak stage V–VI) AD pathology who remained not demented represent only 12% (Nun Study) and 8% (ACT study) of nondemented subjects. Comparison of these subjects to those who were demented revealed that the former group was often significantly memory impaired despite not being classified as demented. Most of these nondemented participants showed only stage V neurofibrillary pathology and frontal tangle counts that were slightly lower than a comparable (Braak stage V) dementia group. In summary, these data indicate that, in individuals with AD-type pathology who do not meet criteria for dementia, neocortical neurofibrillary tangles are somewhat reduced and incipient cognitive decline is present. Our data provide a foundation for helping to define additional factors that may impair, or be protective of, cognition in older adults. |
| Databáze: | OpenAIRE |
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